Publications by authors named "Shengqi Qin"

Background: After achieving a clinical complete response through neoadjuvant chemoradiotherapy, a nonoperative management approach for rectal cancer patients known as Wait and Watch (W&W) has gained increasing attention. However, the W&W strategy has been related to higher local recurrence and ambiguous long-term survival. This meta-analysis compared key prognosis indicators between W&W and surgical treatment in an effort to clarify some long-standing points of confusion.

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Article Synopsis
  • The study investigates the risk factors and outcomes of lymphatic metastasis (LNM) in patients with specific types of adenocarcinoma at the gastroesophageal junction.
  • The analysis of 49 patients identified depth of infiltration, histological type, and lymphatic embolus as key independent risk factors for LNM.
  • Patients without LNM had significantly better survival rates (100% at 1 and 3 years) compared to those with LNM (70% at 1 year and 60% at 3 years), suggesting that surgical interventions like total gastrectomy might enhance prognosis for those with LNM.
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Mesenteric fibromatosis (MF) is a rare tumor (2-4 cases per 1 million people annually) with few presented features. In this case study, we reported five MF patients, one of whom suffered a recurrence. Patients received renogram, colonoscopy, cystoscopy, and gastrointestinal examinations.

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In this work we first developed a murine pancreatic tumor model using CD24(+)CD44(+) pancreatic cancer stem cells (CSC) supported by an electrospun scaffold. Unlike conventional models, the use of CSC and the scaffold, which were biologically and chemically defined, afforded scientists a reliable platform to evaluate novel chemotherapy regimens. CD24(+)CD44(+) CSC successfully initiated tumorigenesis in vitro on the scaffold without suffering apoptosis, evidencing the lack of cytotoxicity of scaffolding materials.

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