Publications by authors named "Shengqi Niu"
Coptisine (COP), a naturally occurring alkaloid, is known for its diverse pharmacological effects and its supportive role in intestinal health. Despite this, the detailed mechanisms behind its therapeutic benefits are not yet fully understood. The objective of this study is to investigate the therapeutic potential of COP for the treatment of Ulcerative Colitis (UC) and to delineate the critical pathways by which it exerts its therapeutic effects.
View Article and Find Full Text PDFJatrorrhizine Alleviates DSS-Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF-B Signaling Pathway.
Evid Based Complement Alternat Med
September 2022
Background: Ulcerative colitis (UC), a kind of autoimmune disease with unknown etiology, has been troubling human physical and mental health. Jatrorrhizine (Jat) is a natural isoquinoline alkaloid isolated from , which has been proved to have antibacterial, anti-inflammatory, and antitumor effects.
Purpose: The purpose is to explore the therapeutic effect of Jat on DSS-induced UC and the mechanism of action.
Article Synopsis
- Huanglian Jiedu Decoction (HLJDD) shows promise for treating sepsis, but its key components and mechanisms aren't fully understood; this study aims to clarify these using network pharmacology and molecular docking techniques.
- The researchers mapped the main components of HLJDD and identified overlapping targets related to sepsis, analyzing them through various databases and constructing a protein-protein interaction (PPI) network.
- Results indicated that major active compounds like quercetin and kaempferol target proteins such as JUN and TNF, influencing processes like gene transcription and apoptosis regulation, with potential signaling pathways including PI3K-AKT and MAPK.
Huanglian Jiedu Decoction Exerts Antipyretic Effect by Inhibiting MAPK Signaling Pathway.
Evid Based Complement Alternat Med
December 2021
Aim: The aim of this study was to explore the antipyretic effect and potential mechanism of Huanglian Jiedu Decoction (HLJDD) on LPS-induced fever in rats.
Materials And Methods: The fever rat model was established by LPS. Anal temperature of rats was measured every 1 hour after modeling.