Synthesizing ordered polar patterns in nonpolar SrTiO nanofilms via wrinkle-induced flexoelectricity.

Ordered polar structures in oxide nanofilms play a pivotal role in the development of nanoelectronic applications. Hitherto, ordered polar structures have been restricted to a limited number of ferroelectric materials, and there is no effective scheme to induce and manipulate ordered polar patterns in centrosymmetric nonpolar nanofilms due to the absence of spontaneous symmetry breaking. Here, we circumvent these limitations by utilizing the wrinkle-induced strain gradient modulation associated with flexoelectricity as a general means of inducing and manipulating ordered polar patterns in nonpolar nanofilms.

Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy against non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) is one of the predominant malignancies globally. Percutaneous thermal ablation (PTA) has gained widespread use among NSCLC patients, with the potential to elicit immune responses but limited therapeutic efficacies for advanced-stage disease. T-helper type 9 (Th9) cells are a subset of CD4 effector T cells with robust and persistent anti-tumor effects.

Oxygen Impurity-Tuned Structure and Adhesion Properties of the Cu/SiO Interface.

The properties of the Cu/SiO interface usually deteriorate in the complex atmospheric environment, which may limit its performance and application in the engineering. Using the reactive molecular dynamics method, we investigate how the mechanical behaviors of the Cu/SiO interface change as it interacts with oxygen impurities. The interfacial oxidation degree could be enhanced as O penetrates into the interface area.

Mechanical Control of Polar Patterns in Wrinkled Thin Films via Flexoelectricity.

Intriguing topological polar structures in oxide nanofilms have drawn growing attention owing to their immense potential applications in nanoscale electronic devices. Here, we report a novel route to mechanically manipulate polar structures via flexoelectricity in wrinkled thin films. Our results present a flexoelectric polar transition from a nonpolar state to uniaxial polar stripes, biaxial meronlike or antimeronlike polar structures, and polar labyrinths by varying wrinkle morphologies.

A superstable, flexible, and scalable nanofluidic ion regulation composite membrane.

Two-dimensional layered membranes with high and stable ion transport properties have various applications in nanofluidic devices; however, their construction remains a considerable challenge. Herein, we develop a superstable aramid nanofiber/graphite composite membrane with numerous one-dimensional and two-dimensional nano-confined interspaces for ultrafast ion transport. The fabricated flexible and scalable membrane exhibits high tensile strength (∼115.

Neoadjuvant Chemoimmunotherapy Increases Tumor Immune Lymphocytes Infiltration in Resectable Non-small Cell Lung Cancer.

Background: Neoadjuvant chemoimmunotherapy treatment (NCIT) has achieved great success for non-small cell lung cancer (NSCLC); however, the intrinsic mechanism underlying this treatment remains unclear.

Methods: Thirty-two patients with stage IIA-IIIC NSCLC who underwent surgery after NCIT were included in this retrospective study. Multiplex immunofluorescence (mIF) staining and image analysis assays were performed on the samples collected before and after NCIT for each patient.

Directly Observing the Evolution of Flexoelectricity at the Tip of Nanocracks.

As an electromechanical coupling between strain gradients and polarization, flexoelectricity is largely enhanced at the nanoscale. However, directly observing the evolution of flexoelectric fields at the nanoscale usually suffers from the difficulty of producing strain gradients and probing electrical responses simultaneously. Here, we introduce nanocracks in , , and samples and apply continuously varying mechanical loading to them, and as a result, huge strain gradients appear at the crack tip and result in a significant flexoelectric effect.

Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients.

Background: Neoadjuvant immunotherapy is emerging as novel effective intervention in lung cancer, but study to unearth effective surrogates indicating its therapeutic outcomes is limited. We investigated the genetic changes between non-small cell lung cancer (NSCLC) patients with varied response to neoadjuvant immunotherapy and discovered highly potential biomarkers with indicative capability in predicting outcomes.

Methods: In this study, 3 adenocarcinoma and 11 squamous cell carcinoma NSCLC patients were treated by neoadjuvant immunotherapy with variated regimens followed by surgical resection.

The relationship between different subtypes of and PD-L1 & tumor mutation burden (TMB) based on next-generation sequencing (NGS) detection in Chinese lung cancer patients.

Background: gene mutations are the most common driver oncogenes in non-small cell lung cancer (NSCLC). We conducted an analysis of the immunological characteristics including tumor mutation burden and programmed death-ligand 1 (PD-L1) expression of different subtypes of in 2880 -mutant NSCLC patients.

Methods: A total of 2,880 patients with NSCLC were included in the study.

Tailoring the nanostructures of electrochemical actuators for fast response and large deformation.

Electrochemical actuators (EAs) can effectively convert electric energy to mechanical energy through chemical reactions. However, the response rate and deformability, two of the crucial and antithetic factors in EA studies, can both hardly be improved just by developing or hybridizing different kinds of materials. In this work, this challenge is overcome through tailoring the nanostructures of EAs.

Nonlinear electrochemomechanical modelling of electrochemical strain microscopy imaging.

Electrochemical strain microscopy (ESM) is a powerful tool to resolve ionic transport and electrochemical processes with a nanoscale resolution. To ascertain the underlying mechanism that governs the signal generation of ESM imaging, a fully coupled nonlinear electrochemomechanical model based on the finite element method is developed and applied to LiMnO particles. The frequency dependence of the ESM response, in particular the response at high frequencies used in the detection regime, is investigated in detail.

Athermal Shape Memory Effect in Magnetoactive Elastomers.

Shape memory materials (SMMs) are usually referred to as materials with the ability to recover the original shape via certain thermal stimulations, such as temperature increase. Such shape memory behaviors achieved thermally usually exhibit slow response due to the constraint of thermal conductivity, leaving a big challenge for situations with temperature and speed requirements. In this work, different from previous shape memory mechanisms, an athermal fast-response shape memory effect (SME) based on the manipulation of magnetization profiles is introduced both experimentally and theoretically.

Rayleigh wave propagation in a homogeneous centrosymmetric flexoelectric half-space.

Although Rayleigh waves are a research topic of constant interest, research on Rayleigh waves in flexoelectric materials is still lacking. This study reports the influences of flexoelectricity, strain gradient elasticity, micro-inertia effect and surface effect on Rayleigh waves in a homogeneous centrosymmetric flexoelectric material half-space. The nonclassical governing equations and boundary conditions are deduced with Hamilton's principle.

Intercalated combination of chemotherapy and erlotinib for stage IIIA non-small-cell lung cancer: a multicenter, open-label, single-arm, phase II study.

Objective: This multicenter, open-label, single-arm, phase II trial evaluated the efficacy and safety of an intercalated combination of erlotinib and gemcitabine/cisplatin or carboplatin in patients with stage IIIA non-small-cell lung cancer (NSCLC).

Registration: This trial is registered with ClinicalTrials.gov, number NCT01297101.

Flexoelectret: An Electret with a Tunable Flexoelectriclike Response.

Because of the flexoelectric effect, dielectric materials usually polarize in response to a strain gradient. Soft materials are good candidates for developing a large strain gradient because of their good deformability. However, they always suffer from lower flexoelectric coefficients compared to ceramics.

Comparison of genomic landscapes of large cell neuroendocrine carcinoma, small cell lung carcinoma, and large cell carcinoma.

Background: The classification of large cell neuroendocrine carcinoma (LCNEC) has generated considerable debate and has been revised since its recognition as a separate entity. Although it shares clinical features with small cell lung carcinoma (SCLC) and was classified with SCLC in the 2015 World Health Organization classification system, numerous studies have revealed inferior treatment outcomes of LCNEC when it was treated as SCLC. Because the incidence of LCNEC is rare, its mutational landscape has not been comprehensively interrogated.

SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4.

Background: Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC).

Methods: In this work, we determined the role of SIRT6 in the EMT of NSCLC cells and identified the key EMT-related genes involved in the oncogenic activity of SIRT6.

Bexarotene inhibits the viability of non-small cell lung cancer cells via slc10a2/PPARγ/PTEN/mTOR signaling pathway.

Background: Thirty to 40 % of non-small cell lung cancer (NSCLC) patients developed higher hypertriglyceridemia in the process of treatment with bexarotene. And bioinformatics studies discovered that the expression of slc10a2 was increased in high-grade hypertriglyceridemia patients. So, we will explore the mechanism which may involve in this process.

Investigation of the 2312 flexoelectric coefficient component of polyvinylidene fluoride: Deduction, simulation, and mensuration.

Flexoelectric effects hold promising applications in sensing, actuating, and energy capturing, and thus it is demanded to measure the flexoelectric coefficient tensors of dielectric materials accurately. In this work, an approach to measuring the effective flexoelectric coefficient tensor component μ of polymeric materials is developed by imposing a torque load upon a half cylindrical specimen. It is proven that μ can be calculated by assessing the electric charge on the axial plane and the strain gradient along the radial direction, both induced by the torque.