Publications by authors named "Shengpeng Shao"
Article Synopsis
- Resistance to immunotherapy in colorectal cancer (CRC) is linked to the enzyme PFKFB3, which is found at higher levels in CRC tissues compared to normal ones.
- Research shows that inhibiting PFKFB3 can reduce tumor growth and is associated with several cancer-related pathways and immune responses.
- High expression of PFKFB3 is tied to immunotherapy resistance, particularly in patients resistant to PD-L1 blockade, highlighting its potential as a therapeutic target to improve treatment outcomes.
An increasing number of studies have shown that Isthmin 1 (ISM1), a secreted protein, is important in tumorigenesis and invasion, including in colorectal cancer (CRC). However, the mechanisms are still unclear. This study aims to explore the function and prognosis capacity of ISM1 in CRC.
View Article and Find Full Text PDFWe investigated the role of the competing endogenous RNA (ceRNA) network in the development and progression of pancreatic adenocarcinoma (PAAD). We analyzed the expression profiles of PAAD and normal pancreatic tissues from multiple GEO databases and identified 457 differentially expressed circular RNAs (DEcircRNAs), 19 microRNAs (DEmiRNAs) and 1993 mRNAs (DEmRNAs). We constructed a ceRNA network consisting of 4 DEcircRNAs, 3 DEmiRNAs and 149 DEmRNAs that regulates the NF-kappa B, PI3K-Akt, and Wnt signaling pathways.
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