Integrated microbiome and metabolome analysis reveals the key role of taurohyocholate in the treatment of hyperuricemia with Lacticaseibacillus rhamnosus 2016SWU.05.0601.

The incidence of hyperuricemia (HUA) is on the rise, posing a significant threat to human health. Several probiotics have shown potential in treating HUA; however, the critical role of intestinal metabolites in this therapy remains inadequately understood. Our study demonstrated that Lacticaseibacillus rhamnosus 2016SWU.

Resting-State Functional Connectivity of the Cerebellum in Patients With Chronic Low Back Pain.

Objective: Chronic low back pain affects nociceptive responses in the cerebellum, which leads to increased pain perception and sensorimotor control dysfunction. This study aimed to investigate altered functional connectivity in the anterior and posterior lobes of the cerebellum during chronic low back pain.

Design: Twenty patients with chronic low back pain and 18 healthy participants underwent 3.

Meta-analyses of the association between the Gly482Ser polymorphism and athletic performance.

Peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) encoded by the gene is a vital regulator of glucose and fatty acid oxidation, mitochondrial biogenesis, and skeletal muscle fibre conversion. Several studies have investigated the association between Gly482Ser polymorphism and athletic performance in humans. However, the results were contradictory.