Case report: Aumolertinib plus gumarontinib in a patient with EGFR mutated non-small-cell lung cancer harboring acquired MET amplification following progression on afatinib plus crizotinib.

Background: Although it remained fully unclear about the optimal regimen for Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistant non-small cell lung cancer (NSCLC) patients with Mesenchymal-Epithelial Transition factor (MET) amplification, the dual inhibition of EGFR inhibitor with MET inhibitor were attempted in clinical practice. There is very limited literature on the subsequent treatment when patients develop the resistance to this combination regimen.

Case Summary: The patient, a 49-year-old female, initially presented with EGFR exon 21 L858R metastatic lung adenocarcinoma, treated successfully with first-line afatinib on September 2022 with a progression-free survival (PFS) of 8.

The Association Between Tumor Burden and the Efficacy of Immunotherapy Among Patients With Non-small Cell Lung Cancer.

Background: This cohort study aimed to evaluate the impact of tumor burden (TB) on the efficacy of immunotherapy in patients with advanced non-small cell lung cancer (NSCLC).

Materials And Methods: Data from the POPLAR and OAK trials were extracted as the training and validation cohorts, respectively. TB was defined as the sum of the longest dimensions (blSLD) of measurable target lesions as per RECIST v1.

Sulfur-oxygen isotope analysis of SO sources in cave dripwater and their influence on the karst carbon cycle.

Sulfuric acid is involved in carbonate rock dissolution in karst areas and affects regional hydrogeochemical and carbon cycling processes. Sulfate sources and carbonate weathering at dripwater points of different hydrological types also differ significantly. Therefore, in this paper, three dripwater points (SQ2#, PB and MH6#) of different hydrological types in Dafeng Cave and Mahuang Cave were selected and systematically analyzed.

Seasonal variations of cave dripwater hydrogeochemical parameters and δC in the subtropical monsoon region and links to regional hydroclimate.

Stalagmites are considered natural archives of climate proxies. However, under the combined effects of atmospheric circulation patterns, precipitation, and karst environments, drip hydrogeochemical processes can be coupled and linked to each other to control cave sediment record information. Therefore, the evolution of chemistry and factors controlling the isotopic composition of the dripwater during regional precipitation migration from the surface to caves need to be evaluated.