A New Species of the Genus Tropidophorus Duméril, Bibron, 1839 (Reptilia: Squamata: Scincidae) from China-Vietnam Border Region in Southeastern Yunnan Province, China.

Based on morphological and genetic data, we describe a new species of Tropidophorus from the tropical karst landscape in southeastern Yunnan Province, China, close to the Vietnam border. Phylogenetically, the new species forms a clade with T. baviensis, T.

An injectable thermosensitive pluronic F127 loaded-nanohydroxyapatite / Polydopamine for promoting sciatic nerve repair after crush injury.

Peripheral nerve injury (PNI) remains an urgent issue due to its huge financial burden and high rate of disability. Here, an injectable HAP/PDA thermosensitive pluronic F-127 (PF-127) hydrogel is proposed for peripheral nerve repair. We investigated the surface characteristics of HAP/PDA and evaluated biocompatibility, cellular proliferation, differentiation, and apoptosis in vitro.

Downregulation of BIRC2 hinders the progression of rheumatoid arthritis through regulating TRADD.

Aim: Rheumatoid arthritis (RA) is a chronic inflammation mediated by an autoimmune response. Baculoviral IAP repeat-containing 2 (BIRC2) and tumor necrosis factor receptor 1-associated death domain protein (TRADD) have been reported to be highly expressed in RA, while their specific roles during RA progression remain unclear. This study aims to explore the specific regulation of BIRC2/TRADD during the progression of RA.

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model.

Microneedle technology can effectively suppress the formation of hypertrophic scarring in both animals and humans. Our previous research has revealed that this is due to the physical contact inhibition effect by using microneedles made of liquid-crystal polymers as the model device. One important factor we didn't study is the influence of the fabrication materials of microneedles.

PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.

Psoriasis, a common skin disease, endangers human physiological and mental health; however, its pathogenesis remains unclear. Keratinocyte proliferation is a typical pathological characteristic of psoriasis. Serine/threonine protein phosphatase 2A (PP2A) is one of the most important phosphatases for maintaining normal phosphorylation levels in humans.

MiR-424 Functions as Potential Diagnostic and Prognostic Biomarker in Melanoma.

Background: Melanoma is one of the most aggressive and lethal skin cancers worldwide. To our knowledge, no specific or sensitive biomarkers have been clinically used to diagnose or predict melanoma prognosis. MicroRNAs (miRNAs) have been shown to regulate oncogenesis and tumor development in various cancers including melanoma.

Photodynamic therapy for basal cell carcinoma of external auditory canal: A case report.

Background: Basal cell carcinoma (BCC) that occurs in the external auditory canal (EAC) is rare. Currently reported cases are mainly treated with surgical resection. Here, we described an early-detected BCC of the EAC, which achieved good results with photodynamic therapy (PDT).