Publications by authors named "Shenghui Shang"
Article Synopsis
- The study examines age-based differences in traumatic spinal cord injury (TSCI) inpatients in China, noting that older patients had longer delays for surgery, a higher likelihood of incomplete injuries, and longer hospital stays compared to younger patients.
- Researchers analyzed medical records from 13,334 TSCI patients across 30 hospitals from 2013 to 2018, finding a significant increase in the number and proportion of elderly patients (≥85 years) during this period.
- Key findings revealed that younger patients were more likely to undergo crucial decompression surgery, while elderly patients had lower hospitalization costs, highlighting important disparities in treatment and care between age groups.
N-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress. However, the characteristics and functions of mRNA m1A modification in primary neurons and oxygen glucose deprivation/reoxygenation (OGD/R) induced remain unclear. We first constructed a mouse cortical neuron OGD/R model and then used methylated RNA immunoprecipitation (MeRIP) and sequencing technology to demonstrate that m1A modification is abundant in neuron mRNAs and dynamically regulated during OGD/R induction.
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- This study is a retrospective epidemiological analysis focusing on the differences in traumatic spinal cord injury (TSCI) based on biological sex in China from 2013 to 2018.
- The study included data from 13,465 TSCI patients across 30 hospitals, revealing a decreasing male-to-female ratio and a faster rise in TSCI cases among females compared to males.
- Key findings showed that while higher-level falls affected more males, females had a higher occurrence of thoracolumbar injuries and less severe neurological damage, indicating the need for sex-specific prevention and treatment strategies.
Article Synopsis
- Cerebral ischaemia-reperfusion injury causes oxygen and glucose deprivation in neurons, a process not previously studied through epitranscriptomics, which examines RNA modifications like m6A.* -
- The study analyzed m6A modification profiles in normal and OGD/R-treated neurons using MeRIP-seq and bioinformatics, revealing crosstalk between m6A mRNA and circRNA.* -
- Findings indicate that specific m6A circRNA production patterns are influenced by the timing of OGD/R treatments, suggesting potential epigenetic mechanisms for understanding and treating related neurological diseases.*
Background: Ischemia-reperfusion injury (IRI) is an important pathophysiological condition that can cause cell injury and large-scale tissue injury in the nervous system. Previous studies have shown that epigenetic regulation may play a role in the pathogenesis of IRI.
Methods: In this study, we isolated mouse cortical neurons and constructed an oxygen-glucose deprivation/reoxygenation (OGD) model to explore the change in DNA methylation and its effect on the expression of corresponding genes.
Unlabelled: This study provides a national estimate of the incidence of hospitalizations and assesses the clinical features and outcomes during inpatient admission due to osteoporotic fractures diagnosed by ICD-10-CM/PCS among the elderly in the USA, using the US Nationwide Inpatient Sample, 2016-2018.
Purpose: To provide a national estimate of the incidence of hospitalizations and assess the clinical features and outcomes during inpatient admission due to osteoporotic fractures (OFs) among the elderly in the USA.
Methods: The study included all inpatients aged 65 years and older who participated in the US Nationwide Inpatient Sample (NIS).
Epigenetic modifications play an important role in central nervous system disorders. As a widespread posttranscriptional RNA modification, the role of the mC modification in cerebral ischemia-reperfusion injury (IRI) remains poorly defined. Here, we successfully constructed a neuronal oxygen-glucose deprivation/reoxygenation (OGD/R) model and obtained an overview of the transcriptome-wide mC profiles using RNA-BS-seq.
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