Objective: The CHOP combined chemotherapy regimen (cyclophosphamide, doxorubicin, vincristine, and prednisone) is commonly used to treat non-Hodgkin Lymphoma (NHL). While these drugs are effective for cancer treatment, they may have side effects on the reproductive system that are poorly studied. This study used a mouse model to investigate the mechanisms of reproductive function impairment induced by the CHOP regimen and developed a predictive model for assessing reproductive damage with a non-invasive procedure.
View Article and Find Full Text PDFSolvent polarity control as an efficient methodology to regulate the chiroptical properties, including spectral shape, width, intensity, wavelength, etc., has emerged as a novel frontier in optical materials design. However, the underling relationship connecting polarity to the optical property remains unclear.
View Article and Find Full Text PDFTKTL1 is a crucial regulatory enzyme in the pentose phosphate pathway (PPP) and plays a significant role in energy synthesis. It is expressed in various tumour tissues, with its expression level closely associated with tumour invasion, metastasis and prognosis. Recent studies utilising proteomic analysis and other methods have highlighted the noteworthy expression of the TKTL1 gene in germ cells, particularly in spermatogonia and ovarian cells.
View Article and Find Full Text PDFThe IL-17 pathway displays remarkably diverse functional modes between different subphyla, classes, and even orders, yet its driving factors remains elusive. Here, we demonstrate that the IL-17 pathway originated through domain shuffling between a Toll-like receptor (TLR)/IL-1R pathway and a neurotrophin-RTK (receptor-tyrosine-kinase) pathway (a Trunk-Torso pathway). Unlike other new pathways that evolve independently, the IL-17 pathway remains intertwined with its donor pathways throughout later evolution.
View Article and Find Full Text PDFIntracytoplasmic sperm injection (ICSI) is a technique that directly injects a single sperm into the cytoplasm of mature oocytes. Here, we explored the safety of single-sperm cryopreservation applied in ICSI. This retrospective study enrolled 186 couples undergoing ICSI-assisted pregnancy.
View Article and Find Full Text PDFPerovskite quantum dots (QDs) have showed excellent optoelectronic properties to extend the application range of novel solid-state lighting, such as perovskite QD based LEDs (QD-LEDs). However, the traditional device structure of perovskite QD-LEDs employed PEDOT:PSS as a hole inject layer (HIL), which impairs stability due to acidic surface characteristics. This study proposes the sputtered NiO films as an HIL to replace acidic PEDOT:PSS.
View Article and Find Full Text PDFBackground & Aims: Olfactomedin 4 (OLFM4) is a glycoprotein that is related to obesity and insulin resistance. This study aims to investigate the role and mechanisms of OLFM4 in nonalcoholic fatty liver disease (NAFLD).
Approach & Results: OLFM4 expression levels were significantly increased in liver samples from NAFLD patients and in cellular and mouse models of NAFLD.
The two-state non-adiabatic potential energy matrices of the CaH system are calculated a diabatization approach by using a neural network model. Subsequently, the adiabatic and non-adiabatic potential energy surfaces (PESs) are constructed based on these non-adiabatic potential energy matrices. Furthermore, based on the adiabatic and non-adiabatic PESs, the Ca(4sS) + H(XΣ+g) → H(S) + CaH(XΣ) reaction is studied using the time-dependent wave packet method.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2023
The new necklace-type molecules were formed by [8-13]CPP and carborane, which further manipulated the size of the macroring, revealing the effect of size on its luminescence behavior. In this work, the effects of ring size on the absorption spectrum, electron excitation and nonlinear optical properties of the compounds were investigated in detail, aiming to reveal an effective way to improve the optical properties of these necklace-type compounds. The absorption spectra of the compounds showed that the size of the CPP ring had little effect on the spectral shape and position, but the electron transition information showed that there were the significant charge transfer within the CPP ring and a gradual enhancement of interfragment charge transfer from the CPP ring to carborane.
View Article and Find Full Text PDFActa Biochim Biophys Sin (Shanghai)
June 2023
Main protease (M ) serves as an indispensable factor in the life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as its constantly emerging variants and is therefore considered an attractive target for antiviral drug development. Benzothiazole-based inhibitors targeting M have recently been investigated by several groups and proven to be promising leads for coronaviral drug development. In the present study, we determine the crystal structures of a benzothiazole-based inhibitor, YH-53, bound to M mutants from SARS-CoV-2 variants of concern (VOCs) or variants of interest (VOIs), including K90R (Beta, B.
View Article and Find Full Text PDFOlfactomedin-4 is a glycoprotein that is upregulated in inflamed gastrointestinal tissues. This study aimed to investigate the role and underlying mechanisms of olfactomedin-4 in ulcerative colitis. C57BL/6 mice and olfactomedin-4 knockout mice were fed dextran sulfate sodium in drinking water to establish a colitis model.
View Article and Find Full Text PDFSmall ubiquitin-like modifier (SUMO) regulates various biological processes, including the MyD88/TICAMs-IRAKs-TRAF6-NF-κB pathway, one of the core immune pathways. However, its functions are inconsistent between invertebrates and vertebrates and have rarely been investigated in lower chordates, including amphioxus and fishes. Here, we investigated the SUMOylation gene system in the amphioxus, a living basal chordate.
View Article and Find Full Text PDFTo enhance understanding of the correlation between the intermolecular interaction and second-order nonlinear optical (NLO) properties, we studied a "molecular tweezer" with two corannulene substituents linked by a tetrahydro[5]helicene imide, which enabled highly sensitive and selective complexation of C/C through convex-concave π-π interactions. The geometric structure, molecular orbitals, intermolecular interactions, electron absorption spectra and second-order NLO properties of the charge-transfer (CT) complexes formed by molecular tweezers and C/C were studied by density functional theory. Larger fullerenes helped to increase the intermolecular interaction and CT, thereby increasing the first hyperpolarizabilities of CT complexes.
View Article and Find Full Text PDFThe chitin-based peritrophic matrix (PM) is a structure critical for both gut immunity and digestion in invertebrates. PM was traditionally considered lost in all vertebrates, but a PM-like chitinous membrane (CM) has recently been discovered in fishes, which may increase the knowledge on vertebrate gut physiology and structural evolution. Here, we show that in zebrafish, the CM affects ingestion behavior, microbial homeostasis, epithelial renewal, digestion, growth, and longevity.
View Article and Find Full Text PDFObjectives: Hyperuricaemia is closely related to metabolic diseases and is receiving increasing attention from all over the world. This study aimed to investigate the prevalence and factors associated with hyperuricaemia in non-obese Chinese population.
Design: Retrospective cross-sectional study.
Background: E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic coiled-coil-containing protein 3 (TACC3) are factors that enhance the stability of spindle fiber.
View Article and Find Full Text PDFBackground: Metabolic associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide. The important role of urid acid (UA) in MAFLD has been widely investigated. Our previous studies unveiled the elevation of serum UA levels independently predicts an increased risk of incident MAFLD.
View Article and Find Full Text PDFCan J Gastroenterol Hepatol
July 2022
Afamin is a member of the hepatokine that are strongly associated with various metabolic diseases. The relationship between afamin and nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aimed to explore the correlation between serum afamin levels and NAFLD.
View Article and Find Full Text PDFObjective: To investigate the mechanism of Xianfang Huoming Decoction (XHD) improving sperm motility in mice with asthenospermia (AS).
Methods: Thirty normal BALB/c mice were randomly divided into six groups, blank control, AS model control, low-dose XHD, medium-dose XHD, high-dose XHD and levocarnitine + vitamin E (LC+VE). The AS model was established in the latter five groups by injection of methotrexate at 0.
Folia Histochem Cytobiol
July 2022
Introduction: The purpose of this study is to elucidate the impact of long non-coding RNA (lncRNA) MIR4435-2HG/microRNA (miR)-125b-5p/ Semaphorins 4D (Sema4D) on colorectal cancer (CRC) cell propagation and migration.
Material And Methods: Sema4D expression in 73 pairs of CRC tissues and matched adjacent normal tissues was measured by qRT-PCR and western blot and its association with pathological characteristics of CRC patients was analyzed by chi-square test. Also, the expression of MIR4435-2HG, miR-125b-5p and Sema4D in CRC cell lines was detected by qRT-PCR and Western blot.
Cobalt sulfide (CoS) is a promising battery-type material for electrochemical energy storage. However, the poor conductivity and slow charge transfer kinetics as well as the deficiency of electrochemically active sites seriously limit their applications. Herein, a class of the P-doping induced hexagonal CoS nanosheets with S defects (P-CoS) derived from Co-based metal organic frameworks (MOFs) supported on carbon nanotube film (CNT) is designed and prepared.
View Article and Find Full Text PDFMolecular dynamics simulations are used to investigate the aggregation of the cross-contacted and non-cross-contacted graphene sheets in n-hexane, 2,3-dimethylbutane, and cyclohexane solvents. The results show that the main driving force of the graphene aggregation is the interaction between the graphene sheets, and the interaction between solvent molecules also contributes to the aggregation slightly. The initial graphene configurations and the solvent molecule structures both have effects on the graphene aggregation speed.
View Article and Find Full Text PDFAt present, there is a general contradiction between permeability and selectivity of reverse osmosis (RO) membranes for desalination; a membrane with higher water permeability will give a lower salt rejection or selectivity, and vice versa. In this work, single-layer nanoporous graphene is used as RO membrane to investigate the effects of pore shape to reduce this contradiction by molecular dynamics simulations. Two kinds of pores (round and rectangular pores) with different sizes are simulated.
View Article and Find Full Text PDFIn this work, we used multi-scale computational simulation methods combined with density functional theory (DFT) and finite element analysis (FEA) in order to study the optical properties of substitutional doped aluminium nitride (AlN). There was strong surface plasmon resonance (SPR) in the near-infrared region of AlN substituted with different alkali metal doping configurations. The strongest electric field strength reached 10 V/m.
View Article and Find Full Text PDFπ-conjugated aromatic diimides with chemical stability, heat resistance, and redox activity have attracted more attention due to their excellent fluorescence quantum yield in solution. The planar perylene diimide (PDI) derivatives generally have aggregation-induced emission quenching in the solid state, while the cyclic trimers based on pyromellitic diimides (PMDIs), naphthalene diimides (NDIs), and PDIs can increase the fluorescence quantum yield in the solid state and have large two-photon absorption cross section, which can be used as excellent nonlinear optical (NLO) materials. Therefore, this paper will study the effects of multiple assembly modes of the three monomers on the NLO responses of materials.
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