Reactions of Cisplatin with Thioredoxin-1 Regulate Intracellular Redox Homeostasis.

Cisplatin is a widely used anticancer drug. In addition to inducing DNA damage, increased levels of reactive oxygen species (ROS) play a significant role in cisplatin-induced cell death. Thioredoxin-1 (Trx1), a redox regulatory protein that can scavenge ROS, has been found to eliminate cisplatin-induced ROS, while elevated Trx1 levels are associated with cisplatin resistance.

Preoperative evaluation of neurovascular relationships for microvascular decompression: Visualization using Brainvis in patients with idiopathic trigeminal neuralgia.

Objective: A precise and accurate evaluation of neurovascular relationships in patients with idiopathic trigeminal neuralgia (ITN) scheduled for microvascular decompression is necessary. Thus, we constructed and evaluated a fusion imaging technique combining multi-source heterogeneous imaging data from three-dimensional magnetic resonance (MR) and computerized tomography venoangiography (CTV), which enabled use of virtual reality to preoperatively assess the neurovascular relationships, in patients with ITN scheduled for microvascular decompression.

Methods: A single-center observational study.

Trigeminal neuralgia associated with cerebellar pial arteriovenous fistula: A case report.

Rationale: Trigeminal neuralgia (TN) is frequently associated with compression at the root entry zone of the trigeminal nerve by an aberrant loop of an artery, tributaries of the petrosal vein, tumors, aneurysm, and vascular malformation. TN associated with a cerebellar pial arteriovenous fistula (PAVF) has not been described previously.

Patient Concerns: A 65-year-old man presented with right-sided TN.

Cranioplasty Using Polymethylmethacrylate Cement Following Retrosigmoid Craniectomy Decreases the Rate of Cerebrospinal Fluid Leak and Pseudomeningocele.

Objective: Cerebrospinal fluid (CSF) leak frequently occurs after retrosigmoid craniectomy. The present study investigated the effects of cranioplasty using polymethylmethacrylate (PMMA) cement to reduce the incidence of CSF leak following retrosigmoid craniectomy as compared with the autologous bone flap combined with titanium plates.

Methods: Two hundred forty-three patients underwent surgeries via retrosigmoid approach for microvascular decompression or tumor resection.

[Microvascular decompression for hemifacial spasm induced by vertebral artery dissecting aneurysm: one case report].

A 61-year-old female presented with 4 years history of left-sided hemifacial spasm. Head MRI and angiography indicated left vertebral artery dissecting aneurysm which compressed ipsilateral cranial nerves Ⅶ and Ⅷ. Microvascular decompression was performed.

A multivariate analysis of the prognostic factors of grade III gliomas.

Background: Glioma is the most common type of malignant brain tumor and the prognosis of glioma is still poor. Moreover, the prognosis of patients diagnosed with grade III gliomas varies significantly. In this study, we assessed the factors that contribute to the prognosis of patients with grade III gliomas.