Publications by authors named "Shenghe Luo"
Article Synopsis
- This study investigates how LncRNA-CIR6 influences the differentiation of mesenchymal stem cells (MSCs) into heart cells in both lab (in vitro) and live mouse models (in vivo).
- Through various techniques like transfection and injections into mice, researchers find that LncRNA-CIR6 significantly boosts the conversion of bone marrow-derived MSCs and human umbilical cord MSCs into cardiogenic cells.
- The results demonstrate that LncRNA-CIR6 not only enhances heart function after damage but also works through the CDK1 protein, helping repair injured heart tissue.
Endocr Connect
November 2023
Article Synopsis
- A study using isolated rat atrial perfusion and DPP-4-/- mice aimed to explore how liraglutide, a GLP-1 analog, affects atrial natriuretic peptide (ANP) secretion and atrial dynamics.
- Findings showed that liraglutide significantly decreased ANP levels and pulse pressure in both ex vivo and in vivo models, while blocking GLP-1 receptors with Exendin9-39 reversed these effects.
- The research also highlighted the role of the PI3K/AKT/mTOR signaling pathway in liraglutide's inhibition of ANP secretion, with additional implications involving the expression of Piezo 1 and cathepsin K.
