Engineered Macrophages Tune Intratumoral Cytokines through Precisely Controlled Self-Pyroptosis to Enhance Bladder Cancer Immunotherapy.

Engineered macrophages are a promising tool for drug delivery and immunotherapy in cancer treatment. However, simultaneous targeted enrichment and controllable immunological activation of these macrophages at the tumor site remains challenging. As a solution, macrophages loaded with an advanced nanoparticle encapsulating CpG-conjugated magnetic nanoclusters (MNC) with indocyanine green (ICG) and nigericin (NIG) (MNC-ICG-NIG@SiO (MINS)), utilizing Se─Se bond-modified SiO, are designed and applied in bladder cancer, which is typically managed surgically, followed by Bacillus Calmette-Guerin (BCG) adjuvant instillation therapy.

Design and Analysis of Systematic Batched Network Codes.

Systematic codes are of important practical interest for communications. Network coding, however, seems to conflict with systematic codes: although the source node can transmit message packets, network coding at the intermediate network nodes may significantly reduce the number of message packets received by the destination node. Is it possible to obtain the benefit of network coding while preserving some properties of the systematic codes? In this paper, we study the systematic design of batched network coding, which is a general network coding framework that includes random linear network coding as a special case.

BAR: Blockwise Adaptive Recoding for Batched Network Coding.

Multi-hop networks have become popular network topologies in various emerging Internet of Things (IoT) applications. Batched network coding (BNC) is a solution to reliable communications in such networks with packet loss. By grouping packets into small batches and restricting recoding to the packets belonging to the same batch; BNC has much smaller computational and storage requirements at intermediate nodes compared with direct application of random linear network coding.

From flat to deep concave: an unusual mode of facet control.

Au particles with rhombic dodecahedron outlines and deep cavities are obtained by epitaxial growth from a triangular nanoplate. An unusual "wrapping" growth that combines ligand-promoted facet-selective growth and site-specific deposition is proposed. Such a templateless growth not only allows the extreme defect-tolerance, but also broadens the synthetic control at the nanoscale.

Targeted pandemic containment through identifying local contact network bottlenecks.

Decision-making about pandemic mitigation often relies upon simulation modelling. Models of disease transmission through networks of contacts-between individuals or between population centres-are increasingly used for these purposes. Real-world contact networks are rich in structural features that influence infection transmission, such as tightly-knit local communities that are weakly connected to one another.

A Protocol Design Paradigm for Batched Sparse Codes.

Internet of Things (IoT) connects billions of everyday objects to the Internet. The mobility of devices can be facilitated by means of employing multiple wireless links. However, packet loss is a common phenomenon in wireless communications, where the traditional forwarding strategy undergoes severe performance issues in a multi-hop wireless network.

Twisting Ultrathin Au Nanowires into Double Helices.

Previously, double helix nanowire was reported by coating Pd/Pt/Au onto Au-Ag alloy nanowire. Here, straight oleylamine-stabilized ultrathin Au nanowires with single crystalline fcc lattice are surprisingly converted into double helix helices upon reacting with Ag in tetrahydrofuran (THF). The obtained Au-Ag helical nanowires contain lattice distinctively different from the fcc lattice and are different in many aspects with the previous system.