Impact of PSMD2 on Gastric Cancer Tissue Stiffness Investigated via Motor-Piezoceramic Coupled Atomic Force Microscopy.

Gastric cancer is one of the deadliest malignant tumors of the digestive tract, and its development and metastasis are regulated by various factors. Some studies have shown that PSMD2 is involved in cancer development by regulating the tumor microenvironment stiffness. However, the exact mechanism is unclear, and effective means to quantify the effect of PSMD2 on gastric cancer tissue hardness are lacking.

An integrated hinged dual-probe for co-target fast switching imaging.

The diversity of functional applications of atomic force microscopes is the key to the development of nanotechnology. However, the single probe configuration of the traditional atomic force microscope restricts the realization of different application requirements for the same target area of a single sample, and the replacement of the working probe will lead to the loss of the target area. Here, the design, simulation, fabrication, and application of a unique atomic force microscope dual-probe are presented, which consists of a pair of parallel cantilevers with a narrow gap and a U-shaped hinged probe base.

Large Range Atomic Force Microscopy with High Aspect Ratio Micropipette Probe for Deep Trench Imaging.

Atomic force microscopy (AFM) has been adopted in both industry and academia for high-fidelity, full-profile topographic characterization. Typically, the tiny tip of the cantilever and the limited traveling range of the scanner restrict AFM measurement to relatively flat samples (recommend 1 µm). The primary objective of this work is to address these limitations using a large-range AFM (measuring height >10 µm) system consisting of a novel repairable high aspect ratio probe (HARP) with a nested-proportional-integral-derivative (nested-PID) AFM system.