Publications by authors named "Shengdong Meng"
Organic metal matrix Mil-88a nano-enzyme for joint repair in the osteoarthritis mouse model.
Front Bioeng Biotechnol
April 2023
Article Synopsis
- This study introduced a new nanomaterial, Mil-88a nanozyme, aimed at treating osteoarthritis (OA) in a mouse model.
- The researchers tested the safety of Mil-88a using CCK-8 assays and live-dead staining before constructing an OA model to examine its effects.
- Results showed that Mil-88a promotes OA-related anabolic gene expression and inhibits catabolic gene expression, leading to improved OA scores, suggesting its potential as a treatment strategy.
The present study aimed to investigate the role of hyperbaric oxygen (HBO) and treatment with vascular endothelial growth factor (VEGF)-loaded microspheres, and HBO plus VEGF on the survival of random skin flaps in rats. The modified McFarlane flap model was established in 40 rats and evaluated within four groups: VEGF (n=10), HBO (n=10), HBO plus VEGF (n=10) and controls (n=10). Seven days following treatment, the necrotic area of the flap was measured.
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