Interferon-stimulated gene subtypes as key indicators of immune landscape and survival outcomes in ovarian cancer.

Purpose: Ovarian cancer (OV) remains the most lethal gynecological malignancy, underscoring the critical need for robust prognostic biomarkers to enhance patient outcomes. In this study, we classified OV patients by their interferon-stimulated gene (ISG) expression profiles and investigated the associations between these subtypes, the immune microenvironment, and survival outcomes.

Methods: We employed consensus clustering in the TCGA-OV cohort (n = 376) to classify patients into ISG-related subgroups.

PTEN inhibits epithelial mesenchymal transition of thyroid cancer cells by regulating the Wnt/β-Catenin signaling pathway.

Objective: The global incidence of thyroid cancer (THCA) has significantly risen in recent years. This study aims to investigate the role and mechanisms of PTEN in epithelial mesenchymal transition (EMT), invasion and migration of THCA cells.

Methods: PTEN expression in THCA was analyzed through bioinformatics databases.

Enhancing CD4+/CD8+ T cell ratio and accelerating recovery in HNSCC patients through immunonutrition intervention.

Objective: Malnutrition is a common issue in patients with head and neck squamous cell carcinoma (HNSCC), leading to compromised immune function and diminished treatment efficacy. This is particularly concerning for therapies targeting the PD-1 pathway, which are pivotal in cancer treatment. The aim of this retrospective study was to explore the potential benefits of immunonutrition in improving immune responses and clinical outcomes for these patients.

Relationship Between A Body Shape Index and Self-Reported Stress Urinary Incontinence Among US Women: A Cross-Sectional Analysis.

Introduction And Hypothesis: Stress urinary incontinence (SUI) is common among women, but its link with A Body Shape Index (ABSI) is not well understood. This study investigates the association between ABSI and SUI risk in women, exploring variations across different subgroups.

Methods: Data from National Health and Nutrition Examination Survey (2001-2020) were analyzed.

Transcription Impairment of TMEM208 by ZBTB14 Suppresses Breast cancer Radiotherapy Resistance.

Zinc finger and BTB domain-containing protein (ZBTB) proteins have been implicated in different cellular processes, including DNA damage responses and cell cycle progression. However, the mechanism by which ZBTB14 modulates radiotherapy (RT) radioresistance (RT-R) remains to be elucidated. We aimed to elucidate the regulation mechanism of ZBTB14 in breast cancer (BC) RT-R.

Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study.

A limited number of cohort studies have explored the impact of serum essential metal elements on blood pressure (BP) or glycolipids and their regulatory mechanism in children. This study aimed to investigate the relationship between serum metal concentrations of iron (Fe), zinc (Zn), calcium (Ca), copper (Cu), and magnesium (Mg) and BP in children, and explore the potential mediating effects of glycolipid profiles. This cohort study included 1993 children (3566 BP measurements) aged 6-14 years in Chongqing, China.

D609 Suppresses Antituberculosis Response by Regulating Dendritic Cells Antigen Presentation.

Objective: To elucidate the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in the antituberculosis (anti-TB) immune response mediated by dendritic cells (DCs).

Methods: In vivo, C57BL/6J mice infected with the Mycobacterium tuberculosis strain H37Rv. Before infection, the mice were pretreated with the PC-PLC inhibitor D609.

Arthritis and Public Health Monitoring: Longitudinal Changes of Triglyceride-Glucose Index Associated with Arthritis in a Cohort of Older Chinese Adults.

The current decade 2021-2030 was designated by the United Nations as the decade of healthy aging, which underlines the need for public health innovation for arthritis clinical care. The triglyceride-glucose (TyG) index is a novel and emerging parameter closely associated with diabetes and cardiovascular diseases and has been suggested to indicate the risk of arthritis. This study examined the longitudinal changes of TyG levels in relation to arthritis among a nationwide cohort of older Chinese adults.

Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation.

HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a prerequisite for the eradication of viral reservoirs. Previous reports have shown that tannic acid (TA) exerts several biological functions, including antioxidant and antitumor activities.

Quercetin-Loaded Melanin Nanoparticles Decorated with Collagenase Mediates Synergistic Immunomodulation and Restores Extracellular Matrix Homeostasis in Liver Fibrosis.

Liver fibrosis is a chronic disease that lacks effective drug treatment. Chronic damage and inflammation lead to the formation of collagen and fibrous scars. However, the excessive accumulation of collagen I significantly hinders the delivery of drugs into liver tissue.

A Novel circ_0075829/miR-326/GOT1 ceRNA Crosstalk Regulates the Malignant Phenotypes and Drug Sensitivity of Gemcitabine-Resistant Pancreatic Cancer Cells.

Although gemcitabine (GEM) is the cornerstone of the treatment of pancreatic cancer (PC), GEM resistance frequently arises. Circular RNA (circRNA) circ_0075829 is highly expressed in PC. However, whether circ_0075829 contributes to GEM resistance of PC is largely unknown.

Multifunctional Prussian blue nanozymes alleviate atherosclerosis through inhibiting the inflammation feedback loop.

Atherosclerosis (AS) is a lipid-driven chronic inflammatory disease characterized by the presence of numerous proinflammatory cytokines, massive reactive oxygen species (ROS) and excess lipids, which together result in an overall inflammatory positive feedback loop in the plaque focus. Due to its excellent enzyme-like activity in ROS scavenging and inflammation inhibition, as well as its photothermal effects in the lipid efflux ability of foam cells, Prussian blue (PB) has greater potential in preventing inflammatory factor loops for enhanced treatment of AS than traditional nanozymes. In this study, the multifunctional nanozyme BSA@PB/Cur was synthesized by self-assembly of bovine serum albumin (BSA) with PB and further encapsulation of the anti-inflammatory drug curcumin (Cur).

Altering Carotene Hydroxylase Activity of DcCYP97C1 Affects Carotenoid Flux and Changes Taproot Colour in Carrot.

CYP97C1 as a haem-containing cytochrome P450 hydroxylase (P450-type) is important for carotene hydroxylation and xanthophyll biosynthesis. Research about this type of hydroxylase was mainly reported in several model plant species which have no specialized tissues accumulating massive carotenoids. The function of CYP97C1 in the horticultural plant, like carrots, was not fully studied.

Comparison of Postoperative Outcomes in Two Lip-Splitting Approaches for Buccal Squamous Cell Carcinoma Ablation.

Objectives: The choice of surgical access for resection and reconstruction of buccal squamous cell carcinoma (BSCC) with the lip-splitting incision is controversial. Thus, this study aimed to evaluate the clinical and functional outcomes of midline lip split with lazy-S incision (MLSI) against the lateral lip-splitting incision (LLSI).

Methods: A retrospective review was conducted on 41 patients with primary BSCC who underwent resection and reconstruction using MLSI approach (n = 19) and LLSI approach (n = 22) between 2022 and 2024.

Functional assembly of surface microbiota of improves nutrient absorption efficiency and growth.

Macroalgae growth depends on biologically available nitrogen, such as ammonium and nitrate, making nitrogen the most common growth-limiting factor for macroalgae. However, the role of surface microorganisms in promoting nitrogen transformation and improving nitrogen utilization by macroalgae remains unclear. In this study, 228 bacterial strains were isolated from the surface of , and high-throughput sequencing revealed significant shifts in the composition of surface bacterial communities under different nitrogen concentrations.

Picosecond Lifetimes of Hydrogen Bonds in the Halide Perovskite CHNHPbBr.

The structures and properties of organic-inorganic perovskites are influenced by the hydrogen bonding between the organic cations and the inorganic octahedral networks. This study explores the dynamics of hydrogen bonds in CHNHPbBr across a temperature range from 70 to 350 K, using molecular dynamics simulations with machine-learning force fields. The results indicate that the lifetime of hydrogen bonds decreases with increasing temperature from 7.

Predictive value of residual active histologic lesions on renal flare in lupus nephritis patients with clinical remission.

Background: Renal flare in lupus nephritis (LN) is a crucial contributing factor to poor kidney outcomes. This study aimed at evaluating the predictive value of residual active histologic lesions on renal flare in proliferative LN patients with clinical remission.

Methods: We retrospectively enrolled LN patients with class III/IV ± V (biopsy 1) who had undergone a protocol repeat biopsy (biopsy 2) at 7.

Lymphoma combined with lung cancer: A case report.

Lymphoma originates from the lymphatic hematopoietic system and is prone to develop second tumors. We reported a case of lymphoma initially manifesting systematic lymphadenopathies and lung space-occupying lymphoma that developed to lung squamous cell carcinoma in 30 months. The diseases once responded satisfactorily to chemotherapy combined with immunotherapy but progressed after 8 months.

Interlimb and Intralimb Synergy Modeling for Lower Limb Assistive Devices: Modeling Methods and Feature Selection.

The concept of gait synergy provides novel human-machine interfaces and has been applied to the control of lower limb assistive devices, such as powered prostheses and exoskeletons. Specifically, on the basis of gait synergy, the assistive device can generate/predict the appropriate reference trajectories precisely for the affected or missing parts from the motions of sound parts of the patients. Optimal modeling for gait synergy methods that involves optimal combinations of features (inputs) is required to achieve synergic trajectories that improve human-machine interaction.

Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson's Disease.

Purpose: Impulse control disorders (ICDs) and excessive daytime sleepiness (EDS) are common symptoms in Parkinson's disease (PD). Few longitudinal studies have focused on the association between EDS and ICDs. This longitudinal study aimed at assessing association between EDS and ICDs in PD.

Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study.

Purpose: This study investigated whether abnormal cerebral activity observed in adolescents and adults with ADHD also occurs in children during the early developmental stages of executive function.

Methods: The study included 52 children with ADHD aged 4.0-9.

Coupling Relationship Between Soil Properties and Plant Diversity Under Different Ecological Restoration Patterns in the Abandoned Coal Mine Area of Southern China.

Understanding the effects of ecological restoration in abandoned coal mines on soil and plant is important to improve the knowledge of ecosystems evolution and facilitate taking appropriate ecological restoration management practices. This study aims to evaluate the coupling relationship between plant diversity and soil properties after ecological restoration in abandoned coal mine area. The plant diversity such as Margalef index (), Simpson index (), Shannon-Wiener index (), and Pielou index (), and soil properties such as soil pH, soil water content (SWC), soil bulk density (SBD), soil organic matter (SOM), available nitrogen (AN), and microbial biomass carbon (MBC) were investigated in four sites of different ecological restoration patterns, T and study the coupling relationship between them.

Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer.

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, as a novel therapeutic methodology, has opened up new possibilities for colorectal cancer patients. However, its actual clinical efficacy requires further enhancement.

The transcription factors ERF105 and NAC72 regulate expression of a sugar transporter gene and hexose accumulation in grape.

Sugar transport plays a pivotal role in determining the productivity of plants and their capacity to act as carbon sinks. In the major fruit crop grapevine (Vitis vinifera L.), the transporter gene Vitis vinifera Sugars Will Eventually be Exported Transporter 15 (VvSWEET15)is strongly expressed during berry ripening.

Angioarchitecture and Endovascular Therapy of Infantile Dural Arteriovenous Fistulas.

Infantile dural arteriovenous fistula (IDAVF) is a rare complex dural arteriovenous fistulas. This study is to provide a comprehensive understanding of the angioarchitecture of arteriovenous shunts in IDAVFs and planning endovascular treatment. Five cases of IDAVF and a literature review were analyzed to characterize the shunt patterns of IDAVFs in terms of anatomic relations to the arterial feeder, sinuses, and cortical veins.