Background: Lymphocyte migration plays a key role in the development of acute graft-versus-host disease (aGVHD). Blocking lymphocyte migration by targeting chemokine receptors, such as CXCR3, may be a promising strategy for preventing and treating aGVHD. Our previous studies have shown that short-term CXCR3 antagonist treatment combined with cyclosporine A alleviated aGVHD.
View Article and Find Full Text PDFAcute graft-versus-host disease (aGVHD) is a lethal complication after allogeneic hematopoietic stem cell transplantation. The mechanism involves the recognition of host antigens by donor-derived T cells which induces augmented response of alloreactive T cells. In this study, we characterized the role of a previously identified novel classical secretory protein with antitumor function-LYG1 (Lysozyme G-like 1), in aGVHD.
View Article and Find Full Text PDFIt is a central issue to improve the separation efficiency of photogenerated charge carriers and the utilization of visible light in the field of photocatalysis. Herein, taking MIL-125(Ti) as a host material, the Pt/MIL-125(Ti) was first prepared by solvothermal method to build the interface of Schottky junction. Ag was then introduced onto the surface of Pt/MIL-125(Ti) to form the interface with the surface plasmon resonance effect.
View Article and Find Full Text PDFImmortalized cell lines are useful for deciphering the pathogenesis of acute leukemia and developing novel therapeutic agents against this malignancy. In this study, a new human myeloid leukemia cell line YBT-5 was established. After more than 1-year cultivation from the bone marrow of a patient with acute monocytic leukemia, YBT cell line was established.
View Article and Find Full Text PDFMagnetic CoFe O -embedded porous graphitic carbon nanocomposites were prepared through a facile solid-phase thermal reaction with NaCl as a template. The material was applied in the magnetic solid-phase extraction process coupled with high performance liquid chromatography with a diode array detector to detect the trace fenpropathrin, cyhalothrin, S-fenvalerate, and bifenthrin in different water samples. The synthesis conditions of nanomaterial including glucose concentration and calcination time on extraction performance for pyrethroid pesticides have been investigated.
View Article and Find Full Text PDFChemotaxis of T cells to acute graft-versus-host disease (aGvHD) target tissues directed by chemokines and their receptors plays a key role in the pathogenesis of aGvHD. Blockade of lymphocyte migration by targeting chemokine receptors may be a viable strategy for the prevention and treatment of aGvHD, which is quite distinguishable from typical efforts to use immunosuppressive medications that have been associated with some side effects. CXCR3 and its ligands have been reported to be correlated with aGvHD pathogenesis.
View Article and Find Full Text PDFObjective: Our preview study found that CCR5 blockade combined with cyclosporine A could attenuate the severity of liver GVHD. But the potential immunological mechanisms have not yet been explored. So our present study was designed to clarify the potential immunological mechanisms in mouse models after allo-HSCT.
View Article and Find Full Text PDFAlthough most of the mantle cell lymphoma (MCL) patients initially responded well to bortezomib (BTZ), the dose-dependent toxicities have greatly limited the application of BTZ to MCL. To investigate the efficacy and mechanism of arsenic trioxide (ATO) with BTZ in inducing apoptosis of MCL cells, two MCL cell lines, along with primary cells from MCL patients (n = 4), were used. Additionally, the NOD-SCID mice xenograft model of Jeko-1 cells was established to study the anti-MCL mechanisms in an in vivo setting.
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