Characterization of the tumor microenvironment in breast cancer brain metastasis.

Objective: The difference in the tumor microenvironment (TME) between primary breast cancer (PBC) and breast cancer brain metastasis (BCBM) is still unknown. Herein, we present the landscape of the TME in PBC and BCBM to better understand the process of BCBM.

Methods: The Gene Expression Omnibus (GEO) database was used to obtain suitable PBC and BCBM data.

Molecular Epidemiological Characteristics of Carbapenem Resistant from Hospital Wastewater.

Background: Hospital wastewater (HWW) promotes the spread of carbapenem resistance genes (CRGs). carry a large number of CRGs in HWW, they may play a role as a suitable reservoir for CRGs, while resistomes in HWW are still poorly characterized regarding carbapenem resistant . Thus, the aim of the study was to evaluate the molecular epidemiological characteristics of carbapenem resistant in HWW.

Genomic and functional characterization of carbapenem-resistant Klebsiella pneumoniae from hospital wastewater.

Background: The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) attracted extensive attention. Information on CRKP from hospital wastewater (HWW) is limited. The aims of this study were to investigate the genomic characteristics and to evaluate the survivability characteristics of 11 CRKP from HWW in a Chinese teaching hospital in Fujian province.

Profile and actual transmissibility of Carbapenem resistance genes: Intracellular and extracellular DNA in hospital wastewater.

The current worldwide spread of carbapenem resistance genes (CRGs) has posed a major public health threat, which continues to grow in severity. Hospital wastewaters (HWWs) are major reservoirs for antibiotic resistance genes, while resistomes in HWWs are still poorly characterized when it comes to CRGs. We comprehensively characterized the profile and actual transmissibility of extracellular CRGs (eCRGs) and intracellular CRGs (iCRGs) in HWWs for the first time.

Phylogenetic Analysis Reveals Distinct Evolutionary Trajectories of the Fluoroquinolones-Resistant ST1193 From Fuzhou, China.

() ST1193 is an emerging fluoroquinolones-resistant and virulent lineage. Large gaps remain in our understanding of the evolutionary processes and differences of this lineage. Therefore, we used 76 ST1193 genomes to detect strain-level genetic diversity and phylogeny of this lineage globally.

Acquisition of a Stable and Transferable -Positive Plasmid With Low Fitness Cost Leading to Ceftazidime/Avibactam Resistance in KPC-2-Producing During Treatment.

The emergence and prevalence of carbapenem-resistant (CRE) have drawn worldwide attention. Ceftazidime/avibactam (CAZ/AVI) gives us a valuable alternative strategy to treat CRE infections. Unfortunately, CAZ/AVI resistance could occur during CAZ/AVI treatment.

Epidemic Potential of O16:H41-ST131: Compared with Pandemic O25b:H30-ST131 Lineage.

Background: O16:H41 is an important subclone among () sequence type (ST) 131, which has risen dramatically in recent years. However, reasons for the rapid increase of O16:H41-ST131 remain unclear. The aim of this study was to compare the pathogenicity and survivability features of O16:H41-ST131 with global epidemic O25b:H30-ST131 lineage.

A Comparative Study of Fluoroquinolone-Resistant Lineages Portrays Indistinguishable Pathogenicity- and Survivability-Associated Phenotypic Characteristics Between ST1193 and ST131.

Background: Sequence type 1193 is a new such lineage among fluoroquinolone-resistant , which has risen dramatically within the last several years. However, reasons for rapid emergence and successful spread of ST1193 remain unclear. The aim of this study was to compare the pathogenicity and survivability features of ST1193 with global epidemic lineage, ST131.

Hospital Wastewater as a Reservoir for Antibiotic Resistance Genes: A Meta-Analysis.

The emergence and dissemination of antibiotic resistance genes (ARGs) in the environment poses a huge global health hazard. Hospital wastewater (HWW), in which a high density of antibiotic residues and antibiotic-resistant bacteria are present, may be a reservoir of ARGs dissemination into the environment. Our meta-analysis comprehensively analyzes the prevalence of ARGs in HWW, as well as the influencing factors in ARGs distribution.

YouTube™ as a source of information for Candida auris infection: a systematic review.

Background: Candida auris is a novel Candida species, and has emerged globally as a multidrug-resistant health care-associated fungal pathogen. YouTube™ (http://www.youtube.