Molecular mechanism and role of miRNA-155 ribonucleic acid in podocyte apoptosis in lupus nephritis: SOCS1 protein expression regulates JAK/STAT pathway transduction.

This study aimed to explore the specific role of miRNA-155 in the process of podocyte apoptosis within the context of lupus nephritis, as well as to elucidate the underlying molecular mechanisms through which miRNA-155 exerts its effects, particularly focusing on the SOCS1/JAK1-STAT1 signaling pathway. To investigate the direct influence of miRNA-155 on podocyte apoptosis, the researchers employed a cultured glomerular podocyte system, in which they transfected these cells with either mimics of miRNA-155 or inhibitors. The subsequent effects on podocyte apoptosis were carefully monitored.