Two new phytoecdysteroids isolated from .

Two new phytoecdysteroids, (24)-20,26-dihydroxy-24(28)-dehydro-28-methyl-ecdysone (), (24)-22,25-epoxy-2,3,14,20-tetrahydroxyergosta-7,24(28)-dien-28-methyl-6-one (), together with eleven known compounds (-) were isolated from the whole plant of L. The chemical structures of the compounds were elucidated by 1D and 2D NMR and HR-ESI-MS and compared with data from the literature. The isolated compounds were evaluated for their inhibitory effects on NO, TNF-α and IL-6 production in LPS-induced RAW 264.

Two new triterpenoid saponins and two new goodyerosides isolated from the whole plant of .

Two new triterpenoid saponins (oleanolic acid 2-hydroxyl-3---D-glucuronopyranoside-6--buthyl ester () and oleanolic acid 2-hydroxyl-3--[-D-glucuronopyranosyl-6'--methylester]-28---D-glucopyranoside ()) and two new goodyerosides (4-methylenefuran-2(5)-one (6'--vanilloyl)--D-glucopyranoside (), 3-hydroxy-2(5)-furanone, 4-(6'--vanilloyl)--D-glucopyranoside ()), together with seven known compounds (-) were isolated from the whole plant of L. The chemical structures of the compounds were determined by spectroscopic analysis (1D and 2D NMR) and HR-ESI-MS. Compounds , and showed significant cytotoxicity towards A549, SK-Hep1 and HeLa cells, with IC values ranging from 1.

A new megastigmane glycoside, a new organic acid glycoside and other constituents with anticomplementary activity from .

A new megastigmane glycoside, (1,5,6,7)-megastigman-3,9-dione-7-en-6,11-diol 11---D-glucopyranoside (), and a new organic acid glycoside, methyl (4 )-4---D-glucopyranosyl-decanoate (), together with eight known compounds (-), were isolated from the aerial parts of Turcz. ex Bess. (Asteraceae).

Two new iridoid glycosides from .

Two new iridoid glycosides, named 3'--benzoyl-dolichocymboside D () and dolichocymboside E (), along with ten known glycosides (), were isolated from the ethanol extract of the whole plants of Moench. The structures of the isolated compounds were elucidated by 1D and 2D NMR and HR-ESI-MS spectra and by comparison with those reported in the literature. This is the first report on compounds and isolated from the family Scrophulariaceae, and compounds were isolated from the genus .

Two new stilbene glucosides and a new benzoic acid derivative from .

Two new stilbene glucosides, -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), -3,5-dihydroxy-4-methoxystilbene 3--D-glucopyranoside (), one new benzoic acid derivative, -4-hydroxy-3-hydroxymethyl-2-butenyl benzoate 4--D-glucopyranoside (), and four known compounds () were isolated from L. The structures of these compounds were elucidated on the basis of spectral data. Anti-inflammatory effects of compounds () were evaluated in terms of inhibition on production of NO, TNF-α and IL-6 in LPS-induced RAW 264.

Four new terpenoids and other metabolites with potential anti-complementary activities from the aerial parts of (Lamiaceae).

In the course of our continuing search for biologically active compounds from medicinal herbs, four undescribed terpenoids including one monoterpenoid glycoside, (1 , 3, 4, 5 )-(-)-1,8-epoxy--menthan-5-ethoxycarbonyl-3---D-glucopyranoside (), one iridoid glycoside, 3'---D-glucopyranosyl-melampyroside (), one sesquiterpene, 1-(2-methylbutanol)-2-pentyl-1,3-cyclohexadiene (), and one triterpenoid, 28-nor-3,18-dihydroxyurs-12-ene (), together with nine known terpenoids (-) were isolated from the dried aerial parts of (Lamiaceae). Their chemical structures were elucidated by detailed spectroscopy (1 D and 2 D NMR), HRESIMS data analysis and acid hydrolysis. Among them, compounds and were isolated from the family Lamiaceae, compounds , and - were identified from the genus and compounds and were reported from the for the first time.

Synthesis, antitumor and antibacterial activities of cordycepin derivatives.

Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2', 5'-hydroxyl and amino groups of cordycepin. The results showed that the inhibitory activities of , , and on A549 were comparable to the positive control gefitinib, and the inhibitory activity of on A549 was better than that of gefitinib. Also, the inhibitory activities of twelve cordycepin derivatives against 1924, 4220 and 3289 were studied.

Two new quinones and six additional metabolites with potential anti-inflammatory activities from the roots of .

Two new quinones, 4-(5-hydroxy-1,4-dioxo-1,4-dihydronaphtha-len-3-ylamino)-butyric acid methyl ester (compound ) and 1,3-dimethoxycarbonyl-8-hydroxy-9,10-anthraquinone (), and six known compounds () were isolated from the roots of Maxim., a member of the Juglandaceae family. The chemical structures of the compounds were elucidated by nuclear magnetic resonance spectroscopy and compared with data from the literature.

A new flavanone glycoside isolated from .

A new flavanone glycoside, (2)-dihydrooroxylin A 7--[-D-apiosyl(12)]--D-glucoside (), and four known compounds () were isolated from L. The chemical structures of these compounds were determined by 1 D and 2 D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. These five compounds () were isolated from the family Boraginaceae for the first time.

Isolation of a new natural kingiside aglucone derivative and other anti-inflammatory constituents from .

A new secoiridoid, (1,5,8,9)-1-methyl-kingiside aglucone (), along with nine known compounds (-), were isolated from the ethanol extract of the stem bark of (Bl.) Hara. The structure of compound was elucidated using HR-ESI-MS, 1D and 2D NMR spectroscopy.

Anti-inflammatory activities of the chemical constituents isolated from .

Twenty-seven compounds including nine triterpenoids (-), eight sterols (-), two ribonucleotides (, ), four phenols (-), three glycosides (-), and one furan () were isolated from the fruiting bodies of (L.) Lloyd. This study is the first confirmation of the presence of the 11 compounds (, , , , , , , -, and ) isolated from the Polyporaceae family, with six of these ( and -) from the genus .

A new diarylheptanoid and a new diarylheptanoid glycoside isolated from the roots of Juglans mandshurica and their anti-inflammatory activities.

A new diarylheptanoid, (2S,3S,5S)-2,3,5-trihydroxy-1,7-bis(4-hydroxy- 3-methoxyphenyl)heptane (1), and a new diarylheptanoid glycoside, (2S,3S,5S)-2,3-dihydroxy-5-O-β-d-xylopyranosyl-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)heptane (2), together with three known compounds, rhoiptelol C (3), rhoiptelol B (4) and 3',4″-epoxy-2-O-β-d-glucopyanosyl-1-(4-hydroxyphenyl)- 7-(3-methoxyphenyl)heptan-3-one (5) were isolated from the roots of Juglans mandshurica (Juglandaceae). The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods. Compounds 1-5 were assayed for their inhibitory effects on the production of NO, TNF-α and IL-6 in LPS-stimulated RAW264.

One new 1,4-napthoquinone derivative from the roots of Juglans mandshurica.

A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods.

A new ribonucleotide from Cordyceps militaris.

One new ribonucleotide, 5'-(3''-deoxy-β-D-ribofuranosyl)-3'-deoxyadenosine (1), and 14 known compounds (2-15) were isolated from an ethanol extract of Cordyceps militaris. The chemical structures of these compounds were determined from 1D and 2D NMR (H-H COSY, HMBC, HMQC and NOESY) and HR-ESI-MS spectra, and results were compared with data from the literature. The effects of all isolated compounds were measured on NF-κB activation, with compound 2 exhibiting significant inhibitory activity against TNF-α-induced NF-κB reporter gene expression in HeLa cells from 3 to 100 μM.

Two new quinones from the roots of Juglans mandshurica.

Two new quinones, 1-hydroxy-5-pentyl-anthraquinone (1) and 4-(5-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-butyric acid methyl ester (2), together with two known quinones, 5-hydroxy-2-(2-hydroxy-ethylamino)-(1,4) naphthoquinone (3) and juglone (4) were isolated from the roots of Juglans mandshurica (Juglandaceae). Their structures were elucidated on the basis of spectral data. Compound 3 was isolated from the Juglans genus for the first time.

Two new diarylheptanoids isolated from the roots of Juglans mandshurica.

Two new diarylheptanoids, ( - )-threo-3',4″-epoxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl)heptan-2,3-diol (1) and (1α,3β,5α,6α)-1,5-epoxy-3,6-dihydroxy-1,7-bis(3-methoxy-4-hydroxy-phenyl)-heptane (2), along with one known diarylheptanoid, rhoiptelol B (3), were isolated from the roots of Juglans mandshurica. The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR including (1)H-(1)H COSY, HMQC, HMBC and NOESY spectroscopic methods.