There is a reciprocal comorbid relationship between periodontitis and type 2 diabetes mellitus (T2DM). Recent studies have suggested that mitochondrial dysfunction (MD) could be the key driver underlying this comorbidity. The aim of this study is to provide novel understandings into the potential molecular mechanisms between MD and the comorbidity, and identify potential therapeutic targets for personalized clinical management.
View Article and Find Full Text PDFPorous structures are an effective way to improve the performance of flexible capacitive sensors, but the pore size uniformity of porous structures is not easily controlled by current methods, which may affect the inconsistent performance of different batches of sensors. In this paper, a high performance capacitive flexible porous GO/PDMS pressure sensor was prepared based on droplet microfluidic technology. By testing the performance of the sensor, we found that the sensor with a flow rate ratio of 1 : 3 has relatively good performance, with a degree of hysteresis (DH) of 8.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2024
Wound healing difficulties in diabetes continue to be a clinical challenge, posing a considerable burden to patients and society. Recently, exploration of the mechanism of wound healing and associated treatment options in diabetes has become topical. Of note, the positive role of hydrogen sulfide in promoting wound healing has been demonstrated in recent studies.
View Article and Find Full Text PDFAm J Orthod Dentofacial Orthop
November 2023
Introduction: The expansion effects of several new microimplant-assisted rapid palatal expanders (MARPEs) manufactured by 3-dimensional printing technology were evaluated by finite element analysis (FEA). The aim was to identify a novel MARPE suitable for treating maxillary transverse deficiency.
Methods: The finite element model was established using MIMICS software (version 19.
Introduction: The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue.
Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by "on-demand" delivery of the anti-inflammatory agent through a pH-sensing mechanism.
Purpose: There is a bidirectional relationship between periodontitis and type 2 diabetes mellitus (T2DM). The aim of this study was to further explore the pathogenesis of this comorbidity, screen out ferroptosis-related genes involved in the pathological process, and predict potential drug targets to develop new therapeutic strategies.
Methods: Common cross-talk genes were identified from periodontitis datasets (GSE16134, GSE10334 and GSE106090) and T2DM databases (DisGeNET and GeneCard).
Purpose: Methacrylic anhydride-modified gelatin (GelMA) hydrogels exhibit many beneficial biological features and are widely studied for bone tissue regeneration. However, deficiencies in the mechanical strength, osteogenic factors and mineral ions limit their application in bone defect regeneration. Incorporation of inorganic fillers into GelMA to improve its mechanical properties and bone regenerative ability has been one of the research hotspots.
View Article and Find Full Text PDFObjective: To assess the accuracy of nursing home self-report of major injury falls on the Minimum Data Set (MDS).
Data Sources: MDS assessments and Medicare claims, 2011-2015.
Study Design/methods: We linked inpatient claims for major injury falls with MDS assessments.