Gaming disorder: Neural mechanisms and ongoing debates.

Background And Aims: The inclusion of gaming disorder as a new diagnosis in the 11th revision of the International Statistical Classification of Diseases (ICD-11) has caused ongoing debate. This review aimed to summarise the potential neural mechanisms of gaming disorder and provide additional evidence for this debate.

Methods: We conducted a comprehensive literature review of gaming disorder, focusing on studies that investigated its clinical characteristics and neurobiological mechanisms.

A narrow band blue phosphor NaBaAlBOCl:Eu for white light emitting diodes.

Exploring new photoexcited phosphors has attracted attention for improving the performance of white LEDs. Here, an NaBaAlBOCl:Eu phosphor with high color purity (94.11%) has been synthesized.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.

Previously, we reported that α-synuclein (α-syn) clusters synaptic vesicles (SV) Diao et al., 2013, and neutral phospholipid lysophosphatidylcholine (LPC) can mediate this clustering Lai et al., 2023.

Synergy of Cu-doping and reconstruction on BiOCO for promoting CO electroreduction over a wide pH range.

A one-pot hydrothermal reaction was proposed to synthesize Cu-doped BiOCO. Doping Cu with smaller electronegativity than that of Bi and electrochemical reconstruction on BiOCO optimize the hybridization between Bi 6p of BiOCO and O 2p of *OCHO, acquiring FE of ∼100% at a current density of >100 mA cm over a wide pH range.

Defining the features and structure of neutralizing antibody targeting the silent face of the SARS-CoV-2 spike N-terminal domain.

Research on virus/receptor interactions has uncovered various mechanisms of antibody-mediated neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, understanding of neutralization by antibodies targeting the silent face, which recognize epitopes on glycan shields, remains limited, and their potential protective efficacy in vivo is not well understood. This study describes a silent face neutralizing antibody, 3711, which targets a non-supersite on the N-terminal domain (NTD) of the spike protein.

The role of the farnesoid X receptor in diabetes and its complications.

Diabetes is a metabolic disease in which tissues and organs are exposed to a hyperglycemic environment for a prolonged period. Long-term hyperglycemia can cause dysfunction of multiple organs and tissues in the body, leading to diabetic complications such as diabetic cardiomyopathy and diabetic nephropathy. Diabetes and its complications have become one of the key issues that seriously threaten the health of people worldwide.

Spatiotemporal variations and driving factors of crop productivity in China from 2001 to 2020.

Human activities have altered the quantity and distribution of cropland, and climate change profoundly affects crop productivity. However, the spatiotemporal patterns and driving mechanisms of crop productivity remain unclear. Here, we analyze the spatiotemporal evolution of Chinese crop productivity using long-term satellite observation data.

Strontium isotope and trajectory method elucidating overseas migration of to Japan.

The oriental armyworm, , generally migrates from eastern to northeastern China in early summer, and some individuals are believed to migrate overseas to Japan depending on meteorological conditions. This potential migration was investigated with the immigrants' strontium radiogenic isotope ratio Sr/Sr and backward flight trajectories from Japanese trapping sites. The results showed that the Sr/Sr ratios of Chinese reared were significantly higher than those of reared insects of Japanese immigration areas.

Cross-Coupling of 1,2,3,4-Tetrachlororodibenzo--dioxin with Six Coexisting Polycyclic Aromatic Hydrocarbons during Photodegradation on a Fly Ash Surface.

The adverse conditions of the garbage incineration process can lead to the generation of dioxins and polycyclic aromatic hydrocarbons (PAHs). This study aimed to investigate the removal efficiency and possible cross-coupling effect of 1,2,3,4-tetrachlorodibenzo--dioxin (1,2,3,4-TCDD) and six coexisting low-molecular-weight PAHs during photodegradation on the fly ash surface. Due to their higher photoreactivity and light-shielding effect, the six PAHs exhibited inhibitory effects on the photodegradation of 1,2,3,4-TCDD, causing a reduction of 4.

Knowledge, attitude, and practice of dental patients toward dental defects and dental fillings in Jinan, Shandong Province, China: a mediation analysis.

Background: Dental filling is a prevalent method for treating dental defects. This study aimed to investigate the knowledge, attitude, and practice (KAP) toward dental defects and dental fillings among dental patients in Jinan, Shandong Province, China.

Methods: This cross-sectional study was conducted at the main campus and several branch campuses of Jinan Stomatological Hospital, and community locations within Jinan city between October 2023, and January 2024.

The moderation effect of GSTM1/GSTT1 gene polymorphisms on the association of sperm mitochondrial DNA copy number and sperm mobility.

Oxidative stress (OS) is believed to be a significant factor in the decline of semen quality, with mitochondrial DNA copy number (mtDNAcn) serving as a sensitive biomarker for both semen quality and mitochondrial dysfunction resulting from oxidative stress. While glutathione S-transferases (GSTs) are commonly known as 'antioxidant' enzymes, there is ongoing debate regarding the relationship between GST genotypes and semen quality. In a study involving 568 male volunteers from the outpatient department of Puyang Reproductive Medicine Center, sperm mtDNAcn, semen quality, and GSTM1/GSTT1 genotypes were analyzed to investigate the potential link between GSTM1/GSTT1 gene variations and semen quality, as well as the impact of GSTs gene variations on the connection between sperm mtDNAcn and semen quality.

Anatomical study and clinical outcomes of endoscopic transoral surgery for benign salivary gland tumors in the parapharyngeal space.

The existing literature provides little insight into the efficacy of transoral endoscopy in exposing benign tumors originating from salivary glands in the parapharyngeal space at the parotid gland base and resecting part of the deep lobe with a safe margin. This study aims to investigate the efficacy of the endoscopic transoral approach for the visualization and resection of such tumors. Through transoral endoscopic cadaveric dissections and surgical procedures, we examined the anatomical structures of the parapharyngeal space and the deep lobe of the parotid gland, identifying key anatomical landmarks.

Pharmacokinetics, Safety, and Immunogenicity of a Biosimilar of Nivolumab (LY01015): A Randomized, Double-Blind, Parallel-Controlled Phase I Clinical Trial in Healthy Chinese Male Subjects.

Background: Nivolumab (Opdivo) is the first anti-PD-1 antibody approved in the world. LY01015 is a potential biosimilar of nivolumab.

Objectives: This phase I study aimed to establish the pharmacokinetic equivalence between LY01015 and the original investigational nivolumab (Opdivo) in healthy Chinese male subjects.

High Efficiency Removal Performance of Tetracycline by Magnetic CoFeO/NaBiO Photocatalytic Synergistic Persulfate Technology.

The widespread environmental contamination resulting from the misuse of tetracycline antibiotics (TCs) has garnered significant attention and study by scholars. Photocatalytic technology is one of the environmentally friendly advanced oxidation processes (AOPs) that can effectively solve the problem of residue of TCs in the water environment. This study involved the synthesis of the heterogeneous magnetic photocatalytic material of CoFeO/NaBiO via the solvothermal method, and it was characterized using different characterization techniques.

Advanced Oxidation Processes of Organic Contaminants.

Concern is growing about the occurrence of emerging organic contaminants in various eco-environments [...

Early-Life Exposure to 4-Hydroxy-4'-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice.

Exposure to bisphenol A (BPA) during gestation and lactation is considered to be a potential risk factor for autism spectrum disorder (ASD) in both humans and animals. As a novel alternative to BPA, 4-hydroxy-4'-isopropoxydiphenylsulfone (BPSIP) is frequently detected in breast milk and placental barrier systems, suggesting potential transmission from the mother to offspring and increased risk of exposure. Gestation and lactation are critical periods for central nervous system development, which are vulnerable to certain environmental pollutants.

Antifungal Activity of the Dichloromethane Extract of CaoHuangGuiXiang Formula Against by in vitro and in vivo Evaluation.

Purpose: CaoHuangGuiXiang (CHGX) formula is a traditional Chinese medicine for the treatment of -related infection. However, its antifungal mechanisms against the emerging fungal pathogen remain unclear. This study aimed to evaluate the antifungal activity of the dichloromethane extract of CHGX (CHGX-DME) and clarified its antifungal mechanims against .