Interplay between energy metabolism and NADPH oxidase-mediated pathophysiology in cardiovascular diseases.

Sustained production of reactive oxygen species (ROS) and an imbalance in the antioxidant system have been implicated in the development of cardiovascular diseases (CVD), especially when combined with diabetes, hypercholesterolemia, and other metabolic disorders. Among them, NADPH oxidases (NOX), including NOX1-5, are major sources of ROS that mediate redox signaling in both physiological and pathological processes, including fibrosis, hypertrophy, and remodeling. Recent studies have demonstrated that mitochondria produce more proteins and energy in response to adverse stress, corresponding with an increase in superoxide radical anions.

Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study.

Aims: This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics.

Methods: A total of 247 normal controls (NC) and 240 patients diagnosed with GIM were enrolled in this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation.

Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer.

Background: Cervical cancer is the fourth most common cancer in women globally, and the main cause of the disease has been found to be ongoing HPV infection. Cervical cancer remains the primary cause of cancer-related death despite major improvements in screening and treatment approaches, especially in low- and middle-income nations. Therefore, it is crucial to investigate the tumor microenvironment in advanced cervical cancer in order to identify possible treatment targets.

Inorganic substrates in frozen solutions: Transformation mechanisms and interactions with organic compounds - A review.

In cold environments, such as polar regions and high latitudes, the freezing of aqueous solutions plays a crucial role in releasing and transforming nutrients, organic compounds, and trace gases. Freezing processes typically affect biogeochemical cycles and environmental processes by reducing the rate of chemical reactions. However, substantial studies have found that some chemical reactions may accelerate unexpectedly under freezing conditions.

Tunable in-plane conductance anisotropy in 2D semiconductive AgCrPS by ion-electron co-modulations.

In-plane anisotropic two-dimensional (2D) semiconductors have gained much interest due to their anisotropic properties, which opens avenues in designing functional electronics. Currently reported in-plane anisotropic semiconductors mainly rely on crystal lattice anisotropy. Herein, AgCrPS (ACPS) is introduced as a promising member to the anisotropic 2D semiconductors, in which, both crystal structure and ion-electron co-modulations are used to achieve tunable in-plane conductance anisotropy.

The Impact of Selective Spatial Attention on Auditory-Tactile Integration: An Event-Related Potential Study.

Background: Auditory-tactile integration is an important research area in multisensory integration. Especially in special environments (e.g.

Supervillin-Mediated ZO-1 Downregulation Facilitates Migration of Cisplatin-Resistant HCT116 Colorectal Cancer Cells.

Supervillin (SVIL), the biggest member of the villin/gelsolin superfamily, has recently been reported to promote the metastasis of hepatocellular carcinoma by stimulating epithelial-mesenchymal transition (EMT). However, little is known about the roles of SVIL in the migration of colorectal cancer cells. Here, we investigated the effects of SVIL on the migration of cisplatin-resistant colorectal cancer cells.

Corrigendum: (Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.

[This corrects the article DOI: 10.3389/fphar.2024.

[Traditional Chinese medicine prevents and treats depression by regulating hippocampal neuroplasticity: a review].

Depression, a heterogeneous disorder with symptoms involving emotion, cognition, and behavior, is characterized by high morbidity, low treatment acceptance, and recurrent episodes. It is expected to become a major disease in the global healthcare burden by 2030. The pathogenesis of depression is complex, involving genetic, environmental, neurological, immune, endocrine and other factors, among which neuroplasticity plays a key role in the development of depression and antidepressant treatment.

Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.

Glioblastoma, the most prevalent malignant brain tumor, is a lethal threat to human health, with aggressive and infiltrative growth characteristics that compromise the clinical treatment. Herein, we developed a vitamin D3-inserted lipid hybrid neutrophil membrane biomimetic multimodal nanoplatform (designated as NED@MnO-DOX) through doxorubicin (DOX)-loaded manganese dioxide nanoparticles (MnO) which were coated with a vitamin D-inserted lipid hybrid neutrophil membrane. It was demonstrated that in addition to chemotherapy and chemo-dynamic therapy efficacy, NED@MnO-DOX exhibited great power to activate and amplify immune responses related to the cGAS STING pathway, bolstering the secretion of type I interferon-β and proinflammatory cytokines, promoting the maturation of DC cells and infiltration of CD8T cells into the glioma tissue, thereby reversing the immunosuppressive microenvironment of glioma from a "cold" tumor to a "hot" tumor.

Integrating network pharmacology and model to reveal the cardiovascular protective effects of kaempferol-3--rutinoside on heart failure.

Kaempferol-3--rutinoside (KR) has an excellent cardioprotective effect, but its mechanism of action is not clear. Network pharmacology was used to predict the signaling pathways, whereas molecular docking was used for preliminary validation of KR binding to targets. AMI model rats with ligated left anterior descending coronary arteries were established.

The Distributions and Dependences of 3D Particle Morphology Characteristics for Crushed and Natural Sands by X-Ray uCT Investigations.

The morphology of an individual particulate refers to its shape characteristics and size properties, which both play important roles for granular matter in physics, mechanics, chemistry, and biology. In this study, ellipsoidality is defined as a 3D shape index for evaluating particle roundness, and an explicit calculation method is applied. The dependences of 3D shape characteristics (aspect ratios, sphericity, and ellipsoidal degree) on particle size (ranges from 0.

Mechanisms of selectivity for azadirachtin in honeybees (Apis cerana): A new strategy for avoiding thiamethoxam ingestion.

The high toxicity of thiamethoxam (Thi) to foragers has threatened the development of bee populations and the use of neonicotinoid pesticides. In this study, we explored the mechanism of selective feeding on azadirachtin (Aza) by foragers to reduce the feeding of Aza-Thi and improve foragers' safety. The results showed that foragers under selective feeding significantly reduced the Aza sucrose solution intake.

The Modulatory Effect of Exogenous Orienting on Audiovisual Emotional Integration: An ERP Study.

Background: In this study, we explored the interplay between exogenous orienting attention and emotional audiovisual integration (AVI) via electroencephalography (EEG).

Methods: We designed a 2 (cue validity: valid, invalid) × 3 (emotion types: happiness, neutral and sadness) × 3 (modality: visual, auditory, audiovisual) discrimination task on the basis of the cue-target paradigm. Twenty-two participants (average age: 21.

Association of GWAS-Reported Variant of Matrix Metalloproteinase 12 Gene with Susceptibility to Ischemic Stroke in Southern Chinese Population.

Background: Accumulating evidence suggests that matrix metalloproteinase (MMP) 12 plays a detrimental role in cerebro-cardiovascular diseases, including ischemic stroke (IS). Previous genome-wide association studies (GWAS) correlated the rs660599 variant to IS risk in Europeans. However, this association is yet to be elucidated in the Chinese population.

The RING-type E3 ligase RIE1 sustains leaf longevity by specifically targeting AtACS7 to fine-tune ethylene production in .

Ethylene is widely recognized as a positive regulator of leaf senescence. However, how plants coordinate the biosynthesis of ethylene to meet the requirements of senescence progression has not been determined. The rate-limiting enzyme in the ethylene biosynthesis pathway is ACC synthase.

(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway.

Introduction: As one of the most common complications of diabetes, diabetic cardiomyopathy (DCM) is the main cause of heart failure in patients with diabetes. However, the lack of effective treatments for DCM remains a clinical challenge. (Pro) renin receptor (PRR) is a member of renin angiotensin aldosterone system (RAAS).

Static-spun mesoporous silica-coated CsPbBr blue fibres: synthesis and fluorescence properties.

Due to their excellent properties, blue CsPbBr quantum dots show great promise for full-colour display and lighting applications. This study used acetonitrile, a polar solvent, to post-treat CsPbBr quantum dots, resulting in a blue shift to 453 nm. To enhance stability, these quantum dots were encapsulated within the pore structure of mesoporous silica.

Assessment of Genetic Diversity and Population Structure of Exotic Sugar Beet ( L.) Varieties Using Three Molecular Markers.

Sugar beet ( L.) is a biennial herb belonging to the Amaranthaceae family. It contributes to approximately 30% of the world's total sucrose production and is an economically important crop.

Design, Synthesis, and Anti-Inflammatory Activity Evaluation of Novel Indanone Derivatives for the Treatment of Vascular Dementia.

Vascular dementia (VaD) is a neurodegenerative disease resulting from cerebral vascular obstruction, leading to cognitive impairment, and currently lacks effective treatment options. Due to its complex pathogenesis, multi-target drug design (MTDLs) strategies are considered among the most promising therapeutic approaches. In this study, we designed and synthesized a series of novel indanone derivatives targeting targets related to vascular health and dementia.

Molecular insights into biological transformation mechanism of sulfathiazole by Chlorella sorokiniana: Deciphering the uptake, translocation, and biotransformation.

As a sustainable approach to wastewater treatment, microalgae have been extensively used to degrade antibiotics. However, the underlying mechanisms involved in the degradation process remain unclear. Therefore, this study investigated the biotransformation mechanism of sulfathiazole (STZ) by Chlorella sorokiniana (C.

ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis.

Cadmium (Cd) has been classified as a Class I carcinogen, but the mechanism of its carcinogenicity is still unknown. Our previous study demonstrated that 2 μM CdCl induced autophagy in A549 cells. In this study, we investigated the role of ATF4/PHGDH in Cd-induced autophagy and increased glycolysis.