- CGA, a peptide from chromogranin A, has been found to protect against brain injury caused by lipopolysaccharide (LPS) in mice models, but the exact mechanism remains unclear.
- Research demonstrated that CGA helps maintain the integrity of the blood-brain barrier (BBB) during LPS-induced sepsis, as evidenced by reduced hyperpermeability and preservation of tight junction proteins.
- The study suggests that the protective effects of CGA involve the PI3K/AKT signaling pathway, indicating it could be a promising therapeutic target for treating septic brain injuries.