Ultrafast Water Transport of Reverse Osmosis Membrane Based on Quasi-Vertically Oriented 2D Interlayer.

Interlayered thin-film composite (i-TFC) membranes based on 2D materials have been widely studied due to their high efficiency in mass transfer. However, the randomly stacked 2D nanosheets usually increase the fluid path length to some extent. Herein, -grown quasi-vertically oriented 2D ZIF-L was introduced as an interlayer for preparing high-performance reverse osmosis (RO) membranes.

Evaluation of split renal dysfunction using radiomics based on magnetic resonance diffusion-weighted imaging.

Background: Accurate and noninvasive assessment of split renal dysfunction is crucial, while there is lack of corresponding method clinically.

Purpose: To investigate the feasibility of using diffusion-weighted imaging (DWI)-based radiomics models to evaluate split renal dysfunction.

Methods: We enrolled patients with impaired and normal renal function undergoing renal DWI examination.

N6-methyladenosine methyltransferase KIAA1429 promoted ovarian cancer aerobic glycolysis and progression through enhancing ENO1 expression.

Background: Despite improvements in prognosis due to advances in treatment, including surgery, genetic screening, and molecular targeted therapy, the outcomes of ovarian cancer (OC) remain unsatisfactory. Internal mRNA modifications are extremely common in eukaryotes; N6-methyladenosine (m6A) alteration has significant effects on mRNA stability and translation, and it is involved in the pathophysiology of numerous diseases related to cancer.

Methods: Bioinformatics analysis, quantitative real-time polymerase chain reaction and Western blotting were used to detect the expression of vir-like m6A methyltransferase associated (KIAA1429) in OC tissues and cell lines.

Research progress of small-molecule drugs in targeting telomerase in human cancer and aging.

Telomeres are unique structures located at the ends of linear chromosomes, responsible for stabilizing chromosomal structures. They are synthesized by telomerase, a reverse transcriptase ribonucleoprotein complex. Telomerase activity is generally absent in human somatic cells, except in stem cells and germ cells.

Performance of machine learning-based coronary computed tomography angiography for selecting revascularization candidates.

Background: Limited studies have investigated the accuracy of therapeutic decision-making using machine learning-based coronary computed tomography angiography (ML-CCTA) compared with CCTA.

Purpose: To investigate the performance of ML-CCTA for therapeutic decision compared with CCTA.

Material And Methods: The study population consisted of 322 consecutive patients with stable coronary artery disease.

Corylin inhibits the progression of Non-small cell lung cancer cells by regulating NF-κB signaling pathway via targeting p65.

Background: Lung cancer is characterized by high-risk and high mortality, among which non-small cell lung cancer (NSCLC) conquers a dominant position. Previous studies have reported that corylin has anti-inflammatory, anti-oxidant, and anti-tumor effects; however, its role in NSCLC cells remains unclear.

Hypothesis: Corylin inhibits the progression of NSCLC cells.

Pharmacological Activity of Quercetin: An Updated Review.

Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of health-promoting effects, quercetin has attracted much attention of dietitians and medicinal chemists. An updated review of the literature on quercetin was performed using PubMed, Embase, and Science Direct databases.

Research progress of CRISPR-based biosensors and bioassays for molecular diagnosis.

CRISPR/Cas technology originated from the immune mechanism of archaea and bacteria and was awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing. Molecular diagnostics is highly valued globally for its development as a new generation of diagnostic technology. An increasing number of studies have shown that CRISPR/Cas technology can be integrated with biosensors and bioassays for molecular diagnostics.

Exploration of the Protective Mechanism of Naringin in the Acetaminophen-Induced Hepatic Injury by Metabolomics.

Naringin is a dihydroflavone which was found in citrus fruits. Previous studies have indicated the antiapoptotic, antioxidative stress, and anti-inflammatory effects of naringin. It can improve many common diseases, including fibrosis or hepatotoxicity, cardiovascular disease, and diabetes.

Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Extract.

This study sought to explore the anticancer mechanism of (PR) extract based on network pharmacology and molecular docking. The potential chemicals of PR were screened through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and relevant literatures. Corresponding targets of active ingredients were found with the help of the UniProtKB database, and therapeutic targets for cancer action were screened with the help of the GeneCards database.

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter.

The upregulation telomerase activity is observed in over 85-90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G-quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT expression and telomere extension.

Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients: A multicenter retrospective cohort study.

Background: The epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients have been widely reported, but the assessment of dose-response relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.

Aim: To determine the dose-response relationship between risk factors and incidence of COVID-19.

Methods: In this retrospective, multicenter cohort study, we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6, 2020.

Maximum chest CT score is associated with progression to severe illness in patients with COVID-19: a retrospective study from Wuhan, China.

Background: The Coronavirus Disease 2019 (COVID-19) pandemic is a world-wide health crisis. Limited information is available regarding which patients will experience more severe disease symptoms. We evaluated hospitalized patients who were initially diagnosed with moderate COVID-19 for clinical parameters and radiological feature that showed an association with progression to severe/critical symptoms.

Asymmetric polyamide nanofilms with highly ordered nanovoids for water purification.

Tailor-made structure and morphology are critical to the highly permeable and selective polyamide membranes used for water purification. Here we report an asymmetric polyamide nanofilm having a two-layer structure, in which the lower is a spherical polyamide dendrimer porous layer, and the upper is a polyamide dense layer with highly ordered nanovoids structure. The dendrimer porous layer was covalently assembled in situ on the surface of the polysulfone (PSF) support by a diazotization-coupling reaction, and then the asymmetric polyamide nanofilm with highly ordered hollow nanostrips structure was formed by interfacial polymerization (IP) thereon.

Development of a clinical decision support system for severity risk prediction and triage of COVID-19 patients at hospital admission: an international multicentre study.

Background: The outbreak of coronavirus disease 2019 (COVID-19) has globally strained medical resources and caused significant mortality.

Objective: To develop and validate a machine-learning model based on clinical features for severity risk assessment and triage for COVID-19 patients at hospital admission.

Method: 725 patients were used to train and validate the model.

The prognostic value of combining the CD8 + lymphocyte density and the circulating lymphocyte ratio in circumferential resection margin biopsy in rectal cancer.

Background: A positive circumferential resection margin (CRM) may result in local recurrence (LR), but the significance remains controversial. We attempted to utilize the lymphocyte ratio (LYMR), neutrophil-lymphocyte ratio (NLR), tumor-infiltrating lymphocyte (TIL) count, and their combinations (TIL-LYMR/TIL-NLR) in predicting LR after rectal resection.

Methods: Patients with rectal cancer who underwent curative resection between January 2016 and December 2018 were enrolled.

Comparative analysis of the male inflorescence transcriptome profiles of an ms22 mutant of maize.

In modern agricultural production, maize is the most successful crop utilizing heterosis. 712C-ms22 is an important male sterile material in maize. In this study, we performed transcriptome sequencing analysis of the V10 stage of male inflorescence.