Publications by authors named "Sheng-xian Jia"
Hypertrophic scar is a major clinical outcome of deep-partial thickness to full thickness thermal burn injury. Appropriate animal models are a limitation to burn research due to the lack of, or access to, animal models which address the endpoint of hypertrophic scar. Lower species, such as rodents, heal mainly by contracture, which limits the duration of study.
View Article and Find Full Text PDFMultipotent mesenchymal stem cells (MSCs) are found in various tissues and can proliferate extensively in vitro. MSCs have been used in preclinical animal studies and clinical trials in many fields. Adipose derived stem cells (ASCs) have several advantages compared to other MSCs for use in cell-based treatments because they are easy to isolate with relative abundance.
View Article and Find Full Text PDFImpaired reepithelialization is a hallmark of chronic, ischemic wounds; however, the pathogenesis of the delayed reepithelialization in these wounds remains poorly understood. Transforming growth factor beta is involved in both the normal and hypoxic wound-healing response and exogenous overexpression of Smad3, which has been known to accelerate reepithelialization. Recently, it was shown in the rabbit ear dermal ulcer model that Ad-Smad3 injection enhanced reepithelialization and granulation tissue formation suggesting a positive effect of Smad3 on wound healing.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to create a rabbit ear model for observing hypertrophic scar formation, using 60 ears from 32 New Zealand white rabbits with full skin defects.
- The healing process was monitored over 12 months after applying silver sulfadiazine cream, with control ears left untreated for comparison.
- Results showed that scar characteristics evolved through overgrowth, maturation, and degeneration, making this model suitable for understanding hypertrophic scars and assessing treatment methods.
[The expression of laminin in the intermingled skin transplantation of allograft and autograft].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2002
Objective: To explore the healing mechanism of full-thickness wound treating by the intermingled skin transplantation of large sheet allograft with autograft through studying the expression of laminin (LN).
Methods: Thirty-six SD rats with 10% to 15% of total body surface area (TBSA) full-thickness were made. After 3 days, the devitalized tissue were excised and transplanted a large sheet of allograft from Wistar rats and islets of autografts were implanted 3 days later.