Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks.

The ovary is the main controller of female fertility, unfortunately, its onset of aging processes was earlier than other organs. Our previous studies showed calcium (Ca) deficiency reduced ovarian weight and declined numbers of dominant follicles in an avian model. However, whether Ca provided a functional role in follicle development of aged avian, and its further mechanism was still unknown.

Nattokinase's Neuroprotective Mechanisms in Ischemic Stroke: Targeting Inflammation, Oxidative Stress, and Coagulation.

Nattokinase (NK), a potent serine endopeptidase, has exhibited a variety of pharmacological effects, including thrombolysis, anti-inflammation, and antioxidative stress. Building on previous research highlighting NK's promise in nerve regeneration, our study investigated whether NK exerted protective effects in transient middle cerebral artery occlusion (tMCAO)-induced cerebral ischemia-reperfusion injury and the underlying mechanisms. The rats were administered NK (5000, 10000, 20000 FU/kg, i.

[Comparison on biological activities of Lycium barbarum polysaccharides extracted with five methods].

Studying the physicochemical properties and biological activities of Lycium barbarum polysaccharides(LBPs) is of great significance. The previous study had extracted LBPs(LBP-1, LBP-2, LBP-3, LBP-4, and LBP-5) by five different methods(cold water extraction, boiling water reflux extraction of the residue after cold water extraction, ultrasonic extraction with 50% ethanol, ultrasonic extraction with 25% ethanol of the residue after 50% ethanol extraction, and hot water extraction). In this study, the structures of the obtained five LBPs were characterized by UV spectroscopy, thermogravimetric analysis, and scanning electron microscopy.

Investigation of Rutting Performance in Geogrid-Reinforced Asphalt by Penetration Test.

Permanent deformation, or rutting, is one of several critical distresses in flexible pavements. This paper introduced a novel experimental method, a penetration test, for asphalt mixtures to quantify the effects of glass fibre geogrids embedded in asphalt under repeated loading. It was found that the evolution of permanent deformation () and its strain rate have three clearly identifiable stages.

Prognostic role of the recepteur d'origine nantais (RON) expression in primary high-grade osteosarcoma.

Background: Osteosarcoma is a common primary malignant bone tumor susceptible to distant metastasis. The clinical outcome for patients remains poor due to the resistance to chemotherapy and lacking effective therapeutic targets. Recepteur d'origine nantais (RON), a transmembrane protein of the c-MET proto-oncogene family, has been reported to contribute to the malignant progression and bone metastasis in several tumors.

Clinicopathological and prognostic value of NADPH oxidase 2 (NOX2) in primary osteosarcoma.

Background: Osteosarcoma is the most common primary malignant bone tumor, particularly among children and adolescents, and the prognosis of osteosarcoma patients remains poor. The NADPH oxidase 2 (NOX2) has been found over-expressed in several human cancers, and closely associated with poor prognosis. Meanwhile the role of NOX2 in osteosarcoma patients has not been reported.

Clinicopathological value of ErbB2 gene and protein expression in osteochondroma.

Objective: The aim of this study was to investigate ErbB2 expression in osteochondroma and its relationship with clinicopathologic features of osteochondroma, so as to identify a new biomarker for the malignant transformation potential of osteochondroma.

Methods: Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) were used to investigate the expression status of ErbB2 protein and gene in 30 osteochondroma tissues and 20 non-neoplastic bone tissues. The association of ErbB2 gene and protein expression with clinicopathological parameters of osteochondroma was analyzed by using the χ2 test and Fishers exact test.

Clinicopathological and prognostic values of ErbB receptor family amplification in primary osteosarcoma.

Osteosarcoma is a malignant bone tumor with extremely high invasion, metastasis and mortality. The prognosis of patients with osteosarcoma remains poor. The ErbB receptor family was found to be overexpressed in human cancers and associated with poor prognosis.

Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma.

Background: Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma.

MicroRNA-885-5p promotes osteosarcoma proliferation and migration by downregulation of cell division cycle protein 73 homolog expression.

Osteosarcoma (OS) is the most common primary malignant bone tumor. Numerous studies have strongly implicated the ectopic expression of microRNAs (miRNAs/miRs), including miR-885-5p, which is aberrantly expressed in several cancer types, in multiple cancer-related processes. However, the role of miR-885-5p in OS remains unknown.

Prognostic significance of the expression of HER family members in primary osteosarcoma.

The prognosis of patients with metastatic osteosarcoma is poor and has shown no significant improvement in nearly 20 years. The human epidermal growth factor (EGF) receptor (HER) family is frequently overexpressed in the majority of human carcinomas, and is involved in promoting the proliferation and survival of cancer cells. However, the role of EGFR and HER-2 expression in osteosarcoma survival remains controversial and no previous study has simultaneously investigated the association of the expression of all the four HER family members with the prognostic significance of osteosarcoma.

[Treatment of sixty-one patients with coronary slow flow phenomenon by yiqi huoxue recipe combined Western drugs: a clinical research].

Objective: To observe the clinical efficacy of treating patients with coronary slow flow phenomenon by Yiqi Huoxue Recipe (YHR) combined Western drugs, thus providing clinical evidence for further studies.

Methods: Totally 61 patients with coronary slow flow phenomenon were randomly assigned to the treatment group (31 cases) and the control group (30 cases). Patients in the control group were treated with basic treatment of Western medicine, while those in the treatment group were treated with basic treatment of Western medicine and YHR.

[Effect of pamidronate on cementoclast and osteoclast differentiation factor expression during orthodontic tooth movement in rats].

Purpose: To investigate the influence of pamidronate on cementoclast and osteoclast differentiation factor(ODF) expression during orthodontic tooth movement in rats.

Methods: 24 female, 6-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established. Each rat's maxillary was divided into experimental side and control side.

[C(2) trans-laminar screws for atlantoaxial instability: preliminary clinical report of nine cases].

Objective: C(2) pedicle screw is the classic instrumentation for posterior C(2) fixation. But it could be dangerous in case of anatomical variation, such as high riding vertebral artery and small C(2) pedicle. C(2) trans-laminar screw could be an alternative choice.

[Analysis of veracity of the C1 lateral mass screw insertion in the atlantoaxial fixation].

Objective: To evaluate the veracity of the C1 lateral mass screw insertion in the atlantoaxial fixation using plate and screw method without A-P fluoroscopic guiding.

Methods: In the atlantoaxial fixation, without A-P fluoroscopic guiding, we probe lateral mass edge and identify the entrance point of C1 lateral mass screw indirectly. 159 patients treated with atlantoaxial fixation using plate and screw method were studied.

[Analysis the reasons of pulmonary embolism after spine surgery in eleven patients].

Objective: To discuss the clinical characteristics, early diagnosis and treatment for pulmonary embolism after spine surgery.

Methods: From January 1995 to May 2006, 11 cases suffered pulmonary embolism after spine surgery in the total of 10 993 patients. The clinical characteristics, diagnosis and treatment of these 11 cases were retrospectively analyzed.

Open reduction of irreducible atlantoaxial dislocation by transoral anterior atlantoaxial release and posterior internal fixation.

Study Design: A retrospective study of surgical outcome of 33 patients with irreducible atlantoaxial dislocation (IAAD).

Objective: To evaluate the safety efficacy of one stage anterior release and posterior fixation and fusion to reduce and stabilize IAAD.

Summary Of Background Data: The traditional treatment of symptomatic IAAD is ventral decompression by transoral approach.

[Reliability of direct probing isthmus of axial vertebrae to defining the screw path in atlas during Magerl technique].

Objective: To evaluate the accuracy and reliability of atlantoaxial transarticular screw insertion (Magerl's technique) in atlas under lateral fluoroscopic monitoring without anteroposterior view.

Method: Seventy-five consecutive patients with atlantoaxial instability, 48 males and 27 females, aged 35.1, were treated by Magerl's technique.

[Effect of bioactive glass filling defective alveolar bone on tooth movement].

Objective: To observe the movement of rat's tooth in the area of defective alveolar bone filled with bioglass in comparison with contralateral tooth.

Methods: Forty female Wistar rats were selected. Defects in alveolar bones were created and filled with bioglass.

[Diagnosis and treatment of esophageal fistula in anterior cervical spine surgery].

Objective: To evaluate the causes, diagnosis, treatment and prevention of esophagocutaneous fistula in anterior cervical spine surgery.

Methods: Thirteen cases with esophagocutaneous fistula in anterior cervical spine surgery were studied.

Results: The causes includes: (1) During the operation, esophagus was oppressed by a clasp for so long time that made a pressure necrosis of the esophagus; (2) Esophagus was injured by loose plates and screws; (3) Loose bone grafts oppressed esophagus; (4) Esophagus was injured by operative appliance in the operation; (5) Esophagus was oppressed by the plate.

[The discrepancy between ICP and MCP caused by orthodontic treatment and its quantitative assessment to the effect of later orthodontic treatment.].

Purpose: To investigate the discrepancy between ICP and MCP caused by orthodontic treatment. to evaluate the treatment effect of the malocclusion with later orthodontic treatment.

Methods: Nineteen cases were selected and treated with preadjusted appliance and combination headgear appliance.

[Preparation of surface functional magnetic microspheres and their application in nucleic acid separation and enzyme immobilization].

Objective: To Prepare surface functional magnetic microspheres for the separation of vascular endothelial growth factor (VEGF) nucleic acid and lactase enzyme immobilization.

Methods: Using suspension polymerization methods to copolymerize MA-styrene containing magnetite nanoparticles and GMA-styrene also containing magnetite nanoparticles, respectively. Both the carboxyl-modified magnetic microspheres and epoxy-modified magnetic microspheres were obtained.