Publications by authors named "Sheng-gu Xie"
[Enantiomeric separation and impurity determination of valaciclovir hydrochloride].
Zhejiang Da Xue Xue Bao Yi Xue Ban
March 2014
Objective: To determine the contents of L-enantiomer impurity in valaciclovir hydrochloride.
Methods: Valaciclovir enantiomers were separated and determined by using chiral high performance liquid chromatography. Chromatographic conditions were as follows:CROWNPAK(®) CR(+) chiral column (4 mm×150 mm, 5 μm), detection wavelength:254 nm, mobile phase:water-methanol-perchloric acid (19:1:0.
Stereoselective glucuronidation of carvedilol by Chinese liver microsomes.
J Zhejiang Univ Sci B
October 2007
Objective: To study the stereoselective glucuronidation of carvedilol (CARV) by three Chinese liver microsomes.
Methods: The metabolites of CARV were identified by a hydrolysis reaction with beta-glucuronidase and HPLC-MS/MS. The enzyme kinetics for CARV enantiomers glucuronidation was determined by a reversed phase-high pressure liquid chromatography (RP-HPLC) assay using (S)-propafenone as internal standard after precolumn derivatization with 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosylisothiocyanate.