Publications by authors named "Sheng-chao Wang"
Article Synopsis
- - Non-small cell lung cancer (NSCLC) is a major health issue, and while traditional treatments like surgery and radiation have negative side effects, research into Traditional Chinese Medicine (TCM) is gaining traction due to its safer profile and potential efficacy.
- - The study aims to explore the antitumor properties of two versions of a specific TCM plant, before and after fermentation, and to understand how they inhibit NSCLC at a molecular level using various analytical techniques.
- - Results showed that the fermented version (TMQ) contained more beneficial compounds and had a greater tumor growth inhibition effect (57.24% vs. 49.62% in the unfermented version) while also affecting key proteins related to tumor growth and immune
Article Synopsis
- Polygonum cuspidatum, found mainly in China, Korea, and Japan, has medicinal roots used to treat high blood sugar and inflammation.
- * The review focuses on recent research regarding the extraction, purification, and pharmacological effects of polysaccharides from Polygonum cuspidatum, highlighting new potential applications.
- * The study analyzed 278 relevant documents, revealing effective extraction methods and significant health benefits of polysaccharides, paving the way for future clinical uses and research.
Background: The role of indoxyl sulfate (IS), an important protein-bound uremic toxin, in arterial stiffness (AS) in patients with chronic kidney disease (CKD) is unclear.
Materials And Methods: We investigated the association between serum IS levels and AS in a cross-sectional study of 155 patients with CKD. Patients in the AS group was defined as carotid-femoral pulse wave velocity (cfPWV) value >10 m/s measured by a validated tonometry system (SphygmoCor), while values ≤10 m/s were regarded as without AS group Serum IS was measured by liquid chromatography-mass spectrometry analysis.
The early detection of cancer can reduce cancer-related mortality. There is no clinically useful noninvasive biomarker for early detection of breast cancer. The aim of this study was to develop accurate and precise early detection biomarkers and a dynamic monitoring system following treatment.
View Article and Find Full Text PDFObjective: To study the effect of DuzhongButiansu Capsules (DBC) on adenine-induced reproductive dysfunction (RD) in male rats.
Methods: Eighty male SD rats were randomly divided into six groups, blank control (n = 8), solvent control (n = 8), RD model control (n = 16), Shengjing Capsules (SJC) (n = 16), low-dose DBC (n = 16) and high-dose DBC (n = 16). The RD model was made by intragastric administration of adenine at 200 mg/kg/d for 5 successive weeks in the latter four groups of animals, and in the meantime the rats in the latter three groups were treated intragastrically with SJC at 0.
Background: Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis, prognosis, and recurrence prediction of colorectal cancer using noninvasive aberrant DNA methylation biomarkers has encouraging potential. The aim of this study is to characterize the DNA methylation of the promoter region of TMEM240, as well as gene expression and its effect on cell biological functions and its applications in early detection and outcome prediction.
View Article and Find Full Text PDFArticle Synopsis
- * The study identified CCND2 as a common target, revealing that promoter hypermethylation occurs in about 40.9% of breast tumors and 44.4% of circulating DNA in patients, indicating its poor prognostic significance.
- * Treatment with the demethylating agent antroquinonol D increased CCND2 expression and inhibited cancer growth and migration, suggesting CCND2 hypermethylation could be a useful diagnostic and therapeutic target.
Objective: To investigate the status of tooth loss and denture restoration in Chinese adults, analyse the changing trend and provide fundamental data for oral health policy.
Methods: According to the protocol of the 4th National Oral Health Survey, a multistage stratified random cluster-sampling method was used to enrol adult subjects aged 35 to 44, 55 to 64 and 65 to 74 years in all 31 provinces, municipalities and autonomous regions of the mainland of China. The status of tooth loss and denture restoration was investigated.
Tracking transplanted stem cells is necessary to clarify cellular properties and improve transplantation success. In this study, we investigate the effects of fluorescent superparamagnetic iron oxide particles (SPIO) (Molday ION Rhodamine-B™, MIRB) on biological properties of human dental pulp stem cells (hDPSCs) and monitor hDPSCs in vitro and in vivo using magnetic resonance imaging (MRI). Morphological analysis showed that intracellular MIRB particles were distributed in the cytoplasm surrounding the nuclei of hDPSCs.
View Article and Find Full Text PDFDNA methyltransferase 1 (DNMT1) catalyzes DNA methylation and is overexpressed in various human diseases, including cancer. A rational approach to preventing tumorigenesis involves the use of pharmacologic inhibitors of DNA methylation; these inhibitors should reactivate tumor suppressor genes (TSGs) in tumor cells and restore tumor suppressor pathways. Antroquinonol D (3-demethoxyl antroquinonol), a new DNMT1 inhibitor, was isolated from Antrodia camphorata and identified using nuclear magnetic resonance.
View Article and Find Full Text PDF[Construction, expression and identification of recombinant plasmid encoding bifunctional protein sflk1-IFN-gamma].
Zhejiang Da Xue Xue Bao Yi Xue Ban
July 2010
Objective: To construct, express and identify the recombinant plasmid pcDNA3.1(+)/sflk1-IFN-gamma encoding bifunctional protein sflk1-IFN-gamma (soluble fetal liver kinase 1 and interferon-gamma).
Methods: sflk1 and IFN-gamma gene fragments were cloned by RT-PCR, and then inserted into pcDNA3.