Publications by authors named "Sheng-Yi Zou"

Article Synopsis
  • FOLFOX regimens, consisting of 5-fluorouracil and oxaliplatin, are commonly used to treat colorectal cancer (CRC), but drug resistance poses a significant challenge to effective treatment.
  • Researchers used various transcriptomic datasets and weighted gene co-expression network analysis (WGCNA) to identify C3 as a key gene linked to resistance against FOLFOX and CRC recurrence.
  • High expression levels of C3 were associated with poor survival outcomes and reduced sensitivity to oxaliplatin, suggesting that C3 could serve as a potential biomarker for improving CRC treatment decisions.
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Background: Non-alcoholic fatty liver disease has become the most common chronic liver disease worldwide, which originates from the accumulation of triglyceride (TG) in the liver. Patients with type 2 diabetes mellitus (T2DM) are considered to have a predisposition to hepatic steatosis. However, the influencing factors for hepatic fat accumulation in T2DM patients remain unclear.

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There is emerging evidence that events occurring before and shortly after birth may be important in determining the risk of childhood-onset type 1 diabetes mellitus (T1DM). We aimed to summarize and synthesize the associations between maternal body mass index (BMI), maternal diabetes mellitus (DM), and maternal smoking during pregnancy and the risk of childhood-onset T1DM in the offspring by performing a systematic review and meta-analysis of observational studies. A random effects model was used to generate the summary risk estimates.

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Background: Globally, kidney cancer is the twelfth most common cancer, accounting for 337 860 cases recorded in 2012. By 2020, this number has been estimated to reach 412 929 or increase by 22%. Over the past few decades, a number of prospective studies have investigated the association between blood pressure (BP) and risk of kidney cancer, using either recorded BP levels or reported hypertension as the principal exposure variable.

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Findings from observational studies have suggested a possible relation between Ca and breast cancer risk. However, the results of these studies are inconclusive, and the dose-response relationship between Ca intake and risk of breast cancer remains to be determined. A meta-analysis of prospective studies was conducted to address these issues.

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Objective: To investigate the prevalence of diabetic at-risk foot and its associated factors.

Methods: A total of 838 hospitalized patients with type 2 diabetes were screened for at-risk foot. Neural and vascular disorders were evaluated by assessing vibration perception thresholds and ankle brachial indexes (ABIs).

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