Publications by authors named "Sheng-Xin Cai"
Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.
View Article and Find Full Text PDFA new cytotoxic metabolite from a deep sea derived fungus, Phialocephala sp.
Yao Xue Xue Bao
October 2010
A new sesquiterpene hydroquinone (1) was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation.
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- Semi-vioxanthin, derived from a marine fungus, was studied for its ability to boost immune response in mouse macrophages by enhancing the production of TNF-alpha and the expression of key immune molecules CD80, CD86, and MHC II.
- The mechanism behind these effects involves the degradation of IkappaB alpha, leading to the activation of the NF-kappaB signaling pathway and the translocation of its p65 subunit into the nucleus, which is crucial for TNF-alpha production.
- Inhibiting pathways like NF-kappaB and specific MAPK pathways (ERK1/2) impaired the immune-enhancing effects of semi-vioxanthin, confirming its role in regulating immune responses.
Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3- dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method.
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