Effect of deep brain stimulation on substantia nigra neurons in a rat model of Parkinson's disease.

Background: Parkinson's disease (PD) is a common neurodegenerative disease, which occurs mainly in the elderly. Recent studies have demonstrated that apoptosis plays an important role in the occurrence and development of PD. Subthalamic nucleus deep brain stimulation (STN-DBS) has been recognized as an effective treatment for PD.

Anterior and middle skull base reconstruction after tumor resection.

Background: Surgical management of skull base tumors is still challenging today due to its sophisticated operation procedure. Surgeons who specialize in skull base surgery are making endeavor to promote the outcome of patients with skull base tumor. A reliable skull base reconstruction after tumor resection is of paramount importance in avoiding life-threatening complications, such as cerebrospinal fluid leakage and intracranial infection.

[Endoscopic endonasal surgery for meningoencephalocele].

Objective: To investigate the management experience with transnasal endoscopic technique for meningoencephalocele.

Methods: Nine patients with endonasal encephalomeningocele were managed by transnasal endoscopic surgery, and the skull base defect was repaired by fascia.

Results: Eight cases were successfully managed at the time of the first operation, and no relapse case was found during 1 to 4 years follow-up.