Publications by authors named "Sheng-Shuai Shan"
The receptor tyrosine kinase Axl is involved in diabetic vascular disease. This study aims to investigate the effect of high glucose on endothelial cells injury and Axl expression in hypoxia condition in vitro, and we present details of the mechanism associated with overexpression of Axl rescue the high glucose injury. Our results showed that high glucose impaired both human umbilical vein endothelial cells (HUVECs) and EAhy926 cells angiogenesis in hypoxia condition.
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- Metabolic syndrome (MetS) is a known predictor of type 2 diabetes mellitus (T2DM), but research on its impact specifically in Mainland China has been limited.
- A 3-year study of nearly 10,000 non-diabetic Chinese individuals found that MetS significantly increases the risk of developing T2DM, especially when adjusted for age, with higher accuracy in females compared to males.
- The predictive model based on MetS demonstrated good specificity and negative predictive value, suggesting it could enhance prevention strategies for T2DM in Mainland China, although there are some limitations regarding sensitivity and risk overestimation in females.
Background: Evolocumab (AMG 145), a PCSK9 inhibitor, has been shown to decrease low-density lipoprotein cholesterol (LDL-C) levels. Doses of 140mg administered every 2weeks (Q2W) and 420mg administered every 4weeks (Q4W) are widely used, and both dosing schedules were effective in clinical trials. However, some researchers have speculated that 140mg Q2W administration has equal or even greater efficacy.
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