[Reversal Effect of NVP-BEZ235 on Doxorubicin-Resistance in Burkitt Lymphoma RAJI Cell Line].

Objective: To study the reversal effect of NVP-BEZ235 on doxorubicin resistance in Burkitt lymphoma RAJI cell line.

Methods: The doxorubicin-resistant cell line was induced by treating RAJI cells with a concentration gradient of doxorubicin. The levels of Pgp, p-AKT, and p-mTOR in cells were detected by Western blot.

Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum.

Four new diphenyl ethers, named epicoccethers K-N (1-4), were purified from the fermentation medium of a fungus Epicoccum sorghinum derived from Myoporum bontioides, and identified through HR-ESI-MS and NMR spectral analysis. Except that compound 1 showed moderate antifungal activity against Penicillium italicum and Fusarium graminearum, the other three compounds showed stronger activity against them than triadimefon. All of them showed moderate or weak antibacterial activity towards Staphylococcus aureus and Escherichia coli with O6 and O78 serotypes except that 3 was inactive to E.

[Detection of Camellia Oleifera Oil Adulterated with Sunflower Oil with Near Infrared (NIR) Spectroscopy and Characteristic Spectra].

Camellia oleifera oil has the reputation of “oriental olive oil”; it is important to detect the adulterated camellia oleifera oil. In this paper, NIR spectra were used to detect camellia oleifera oil adulterated with sunflower oil. Camellia oleifera oil adulterated with varying mass fraction of sunflower oil were prepared, i.

[Optimization of Stabilizing Agent of Camptothecin Extraction from Nothapodytes pittosporoides Roots].

Objective: To optimize the stabilizing agent of camptothecin extraction from Nothapodytes pittosporoides roots.

Methods: The single factor experiment had been conducted to study the impact on the yield of camptothecin with different kinds of stabilizer, stabilizer concentration and temperature.

Results: The results showed that with 0.

[Feasibility and outcome of rotational atherectomy for treating resistant chronic total occlusions].

Objective: To assess the application of rotational atherectomy to improving the success rate and outcome of percutaneous recanalization of resistant chronic total occlusion (CTO), i.e. the guidewire could cross the lesion but it is impossible to advance any device over the wire through the occluded segment.

[A study on image processing of digital radiography and measure of material micro-density directly].

Due to the high influents of the device itself and the surrounding environment, the background brightness of the digital radiography image is uniform and the image shows big noise. Therefore, in order to identify digital radiography images precisely, a further image processing is necessary. In this study, adaptive filtering, histogram equalization techniques and difference image methods were used for image processing and the results show that these techniques were useful to denoise, to intensify brightness and to rectify the background.

Crystal structure of mastoparan from Polistes jadwagae at 1.2 A resolution.

Mastoparans, a group of amphiphilic tetradecapeptides, are the major peptides in social wasp venoms and possess a variety of biological activities. Here we report the first crystal structure of mastoparan from Polistes jadwagae (MP-PJ) at 1.2 A resolution.

Conformational changes in the reaction of pyridoxal kinase.

To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.

Crystal structure of a NO-forming nitrite reductase mutant: an analog of a transition state in enzymatic reaction.

I257E was obtained by site directed mutagenesis of nitrite reductase from Achromobacter cycloclastes. The mutant has no enzyme activity. Its crystal structure determined at 1.