Publications by authors named "Sheng-Ping Lei"
Article Synopsis
- Renal fibrosis is a key issue in chronic kidney disease leading to kidney failure, and there are currently no therapies to stop its progression.
- A study found that Poricoic acid A (PAA), derived from Poria cocos, effectively reduces renal damage and collagen buildup in a mouse model of renal fibrosis caused by unilateral ureteral obstruction.
- PAA works by inhibiting processes like epithelial-to-mesenchymal transition (EMT) and endoplasmic reticulum stress (ERS), as well as reducing apoptosis in kidney cells, indicating its potential as a treatment for renal fibrosis.
This paper was aimed to investigate the relationship between autophagy and NLRP3 inflammasome activation by studying the effect oftotal flavonoids in Scutellaria barbata (TF-SB) on autophagy in tumor cells and NLRP3 inflammasome, and to provide experimental evidence for further study of the anti-tumor mechanism of TF-SB. Mielanoma models were established by inoculating B16-F1 cell line to mice, and then were randomly divided into 5 groups (n=10 in each group): model control, positive control control(Rap, 1.5 mg•kg⁻¹), and TF-SB low, middle and high groups (50, 100 and 200 mg•kg⁻¹).
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