Effects of rhein on intestinal epithelial tight junction in IgA nephropathy.

Aim: To investigate the effects of rhein on intestinal epithelial tight junction proteins in rats with IgA nephropathy (IgAN).

Methods: Twenty-eight female Sprague-Dawley rats were randomly divided into four groups (7 per group): Control, IgAN, Rhein-treated, and Rhein-prevented. Bovine serum albumin, lipopolysaccharide and CCl4 were used to establish the rat model of IgA nephropathy.

Protection of rhein on IgA nephropathy mediated by inhibition of fibronectin expression in rats.

Objective: To investigate the protective effects of rhein on IgA nephropathy (IgAN) in the rat model.

Materials And Methods: Twenty-eight female sprague dawley rats were divided randomly into four groups, namely control, IgAN, rhein-prevented and rhein-treated. The pathologic changes on renal tissue were observed by the H and E, staining and the amount of urinary red blood cells and 24-h urinary protein excretion were measured.