Publications by authors named "Sheng-Lin Xiong"
Article Synopsis
- - Sphingosine-1-phosphate (S1P) is an important signaling molecule involved in various cellular functions, primarily sourced from vascular endothelial cells and primarily associated with HDL lipoproteins.
- - The study found that apoA-I, a key component of HDL, enhances the production and release of S1P from human umbilical vein endothelial cells (HUVECs) through mechanisms involving ABCA1 and SR-BI proteins, activating the ERK1/2 and SphK pathways.
- - The process of S1P release from endothelial cells triggered by apoA-I is cyclic and self-amplifying, implying that the interaction between apoA-I and the HDL components not only releases S1
High-density lipoprotein (HDL) has a significant cardioprotective effects. HDL induces cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in vascular endothelial cells, which contributes to its anti-atherogenic effects. However, the underlying mechanisms are not fully understood.
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- Plasma concentrations of high-density lipoprotein cholesterol (HDL-C) are linked to a lower risk of cardiovascular problems, highlighting HDL's complex role beyond just lipid transport.
- HDL's effectiveness is influenced by various enzymes, receptors, and its interactions within the cell environment, which can modify its structure and function.
- The review discusses four key mechanisms that could enhance HDL's therapeutic potential: recruiting HDL signals through caveolae, leveraging scavenger receptor class B type I (SR-BI) for signaling, using lecithin-cholesterol acyltransferase (LCAT) for lipid concentration, and delivering microRNAs through HDL to specific targets.
It is well-known that sphingosine-1-phosphate (S1P), the phospholipid content of HDL, binding to S1P receptors can raise COX-2 expression and PGI(2) release through p38MAPK/CREB pathway. In the present study we assess the action of SR-B1 initiated PI3K-Akt-eNOS signaling in the regulation of COX-2 expression and PGI(2) production in response to HDL. We found that apoA1 could increase PGI(2) release and COX-2 expression in ECV 304 endothelial cells.
View Article and Find Full Text PDFABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate.
Clin Chim Acta
February 2012
Sphingosine-1-phosphate (S1P) is a zwitterionic lysophospholipid generated by the sphingosine kinase-catalyzed phosphorylation of sphingosine. A number of the biological effects of S1P are mediated by its binding to five specific G protein-coupled receptors located on the cell surface or intracellular targets. However, the synthesis and secretion of S1P require release out of cells for binding with receptors by certain transporters and carriers.
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