Publications by authors named "Sheng-Lin Pei"
Introduction: Lung injury, a common complication of sepsis, arises from elevated reactive oxygen species (ROS), mitochondrial dysfunction, and cell death driven by inflammation. In this study, a novel class of ultrasmall nanoparticles (CuO USNPs) was developed to address sepsis-induced lung injury (SILI).
Methods: The synthesized nanoparticles were thoroughly characterized to assess their properties.
Article Synopsis
- * A new fluorescence probe based on resorufin was developed to detect different biogenic amines, showing a quick response time under 8 minutes and a low detection limit of 0.47 μM.
- * The probe is not harmful to cells, easily passes through membranes, and has been successfully used to visualize biogenic amines in live cells and zebrafish.
Objective: To evaluate the effects of urinary kallidinogenase on subarachnoid hemorrhage (SAH) in rabbits.
Methods: Rabbits symptomatic cerebral vasospasm model was built though Endo method, among the 40 rabbits, 8 died or had severe nervous system syndrome, the other 32 were randomly divided into 4 groups:group A, control group, injection of normal saline to the cisterna magna;group B, subarachnoid hemorrhage;group C, injection of human urinary tissue kallikreins;group D, treated with Nimodipine. The behavior scores, neurological scores and cerebral angiography changes were observed.
[Effects of human tissue kallikrein on cerebral vasospasm: experiment with rabbits].
Zhonghua Yi Xue Za Zhi
July 2008
Objective: To study the effects of human tissue kallikrein (HTK) on symptomatic cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH).
Methods: Forty rabbits underwent occlusion of bilateral carotid. Two weeks later the 28 surviving rabbits were randomly divided into to 4 groups: shamed-operation group (n = 8) undergoing injection of normal saline into the cisterna magna on day 1 and day 3, SAH group (n = 6) undergoing injection of nonheparinized autologous arterial blood into the cisterna magna, HTK therapy group (n = 6) undergoing blood injection into the cisterna magna and then injection of HTK via ear marginal vein daily for 3 days, and nimodipine (ND) therapy group (n = 6) undergoing blood injection into the cisterna magna and then injection of ND via ear marginal vein.
Objective: To observe the effect of transcutaneous acupoint electrical stimulation (TAES) on brain tissue oxygen and glucose metabolism of the brain tissue in peri-operative period of the craniocerebral operation.
Methods: Fifty patients scheduled for neuro-surgery were randomly assigned to the treatment group and the control group equally. Anesthesia applied after induction on all patients was continuous sevoflurane inhalation and intermittent intravenous injection of sulfenany and vecurnium bromide, but to the treatment group TASE was applied additionally from 30 min before anesthesia to the end of operation.