Publications by authors named "Sheng-Kun Li"

Introduction: Animal models are valid for research on the pathophysiological process and drug screening of gout arthritis. Intra-articular injection of monosodium urate (MSU) is the most common method, while stable MSU deposition enveloped by inflammatory cells was rarely reported.

Objective: To develop a modified gouty arthritis rat model characterized by intra-articular MSU deposition and continuous joint pain with a minimally invasive method.

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Fiscal support measures have different implications for public finances in the near term and beyond the COVID-19 pandemic. For this purpose, this paper examines the determinants of governments' fiscal support in response to the COVID-19 pandemic. The empirical analysis is based on the cross-sectional data estimations from 129 developed and developing countries.

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Both percutaneous and arthroscopic techniques have been introduced in anatomic ankle lateral ligaments reconstruction. The purpose of this study was to compare these two techniques in identifying the calcaneal insertion of the calcaneofibular ligament (CFL). Fifteen fresh-frozen human ankle cadaver specimens were used in this study.

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Purpose: This study aimed to investigate the results of arthroscopic treatment combined with ankle stabilization procedure for sinus tarsi syndrome (STS) in patients with chronic ankle instability (CAI).

Methods: A total of 57 patients (31 males and 26 females, average age 29.9 ± 8.

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Article Synopsis
  • * The derivative known as compound 6ad showed the strongest antifungal activity against several types of fungi, with very low effective concentrations.
  • * Additionally, 6ad proved effective in real-world applications by controlling various rice and crop diseases caused by these fungi, suggesting potential for future development as a fungicide.
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The title compound, C23H35NO2, is an amide derivative of the lactone (+)-sclareolide, and was synthesized from natural sclareol. In the mol-ecular structure, the two six-membered rings (A and B) of the labdane skeleton are trans-fused, and adopt chair conformations. There is an intra-molecular N-H⋯O hydrogen bond present forming an S(7) ring motif.

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The title compound (common name: sclaral), C16H28O2, is a sclareolide derivative, which was synthesized from sclareolide itself. In the mol-ecule, the two six-membered rings, A and B, of the labdane skeleton adopt chair conformations and the five-membered O-containing heterocyclic ring C displays an envelope conformation, with the methine C atom of the fused C-C bond as the flap. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming chains propagating along [100].

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Article Synopsis
  • Researchers created new antifungal compounds called 1,2,3-triazole phenylhydrazone derivatives and confirmed their structures using various analytical methods like NMR and X-ray diffraction.
  • The antifungal effectiveness of these compounds was tested against four harmful fungi, with one compound (5p) showing particularly strong activity and low effective concentration values.
  • Further studies included in vivo tests, where compound 5p successfully controlled various fungal diseases in crops, and a 3D-QSAR model was developed to identify and design even more effective fungicides.
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A series of 1-acyl-3-isopropenylbenzimidazolone derivatives were synthesized, and their structures were characterized by (1)H and (13)C NMR and elemental analysis. Their fungicidal activities against Botrytis cinerea were also evaluated by spore germination assay. The acrylic acid, methacrylic acid, 4-chlorophenyl acetic acid, and 2-chlorobenzoic acid derivatives exhibited strong fungicidal activity.

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