Publications by authors named "Sheng-Hui Qin"
p120-catenin (p120), an E-cadherin regulator, has been implicated as central to a series of genetic and epigenetic changes that ultimately lead to tumor progression and metastasis. Ras-related C3 botulinum toxin substrate 1 (Rac1)and p21-activated kinases (PAKs) are effectors of p120. In the present study, we examined the expression of p120, Rac1 and Pak1 using immunohistochemistry in human gastric cancer tissues.
View Article and Find Full Text PDFExpressions of E-cadherin, p120ctn, β-catenin and NF-κB in ulcerative colitis.
J Huazhong Univ Sci Technolog Med Sci
June 2015
This study was aimed to investigate the expressions of E-cadherin, p120ctn, β-catenin and NF-κB in ulcerative colitis (UC) tissues and the implications of their expressions in the pathogenesis of UC. The expressions of E-cadherin, p120ctn, β-catenin and NF-κB were detected by immunohistochemistry, and those of p120ctn and NF-κB by Western blotting in 23 cases of UC and 17 cases of normal colonic tissues. The relationship between the expression of E-cadherin or NF-κB and that of p120ctn was analyzed by Spearman rank correlation analysis.
View Article and Find Full Text PDFCorrelation of Forkhead Box c2 with subtypes and invasive ability of invasive breast cancer.
J Huazhong Univ Sci Technolog Med Sci
December 2014
Article Synopsis
- FOXC2 is a member of the forkhead transcription factor family and its role in invasive breast cancers, particularly basal-like breast cancer (BLBC), is still not fully understood.
- In a study analyzing 103 invasive breast cancer cases and 15 normal breast samples, it was found that FOXC2 was mostly weakly expressed in invasive cancers but strongly expressed in 60.7% of BLBCs, indicating a potential link to cancer aggression.
- The research concluded that FOXC2 expression correlates with several clinical factors and suggests that FOXC2 may serve as a valuable marker for diagnosing and predicting the prognosis of invasive breast cancer subtypes.