A Comparative Study on Three Treatment Approaches to Applying Topical Botulinum Toxin A for Crow's Feet.

Objective: To evaluate the efficacy and safety of three treatment approaches to applying Botulinum Toxin Type A (BoNTA) for crow's Feet.

Methods: Thirty female subjects with moderate-to-severe crow's feet were included in this comparative study. They were randomly divided into three groups, including the local intramuscular, intradermal microdroplet injection, and nanomicroneedle delivered with BoNTA therapy group.