Prenylated Bibenzyls from the Chinese Liverwort and Their Mitochondria-Derived Paraptotic Cytotoxic Activities.

Nine new prenylated bibenzyls, radstrictins A-I (-), and 11 known congeners were obtained from the Chinese liverwort . Their structures were identified by analysis of HRMS, NMR, and electronic circular dichroism data. Radstrictins A-F (-) were isolated as a racemate or scalemic mixtures.

The novel lncRNA is pro-neurogenic and mutated in human neurodevelopmental disorders.

Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy number variation morbidity maps of a cohort of children with autism spectrum disorder/intellectual disability versus healthy controls revealed focal genomic mutations affecting several lncRNA candidate loci. Here we find that a t(5:12) chromosomal translocation in a family manifesting neurodevelopmental symptoms disrupts specifically .