Daphnetin Modulates Immune Balance and Enhances Pregnancy Viability in a Mouse Model of Unexplained Recurrent Abortion.

Background: Our previous research revealed that daphnetin (7,8-dihydroxycou-marin) positively influences the balance between forked transcription factor P3 (+) regulatory T cells (Treg) and T helper 17 (Th17) cells in the peripheral blood mononuclear cells of individuals with unexplained recurrent pregnancy loss. However, the specific mechanism remains unclear. This research aims to further examine how daphnetin regulates the Th17 cell/+ Treg cell imbalance in a mouse model with unexplained recurrent spontaneous abortion (URSA).