Subphrenic Lymph Node Metastasis Predicts Poorer Prognosis for Nasopharyngeal Carcinoma Patients With Metachronous Metastasis.

Aim: We retrospectively analyzed the distribution of distant lymph node metastasis and its impact on prognosis in patients with metastatic NPC after treatment.

Methods: From 2010 to 2016, 219 NPC patients out of 1,601 (182 from the Affiliated Cancer Hospital and Institute of Guangzhou Medical University, and 37 from the Affiliated Dongguan Hospital, Southern Medical University) developed distant metastasis after primary radiation therapy. Metastatic lesions were divided into groups according to location: bones above the diaphragm (supraphrenic bone, SUP-B); bones below the diaphragm (subphrenic bone, SUB-B); distant lymph nodes above the diaphragm (supraphrenic distant lymph nodes, SUP-DLN); distant lymph nodes below the diaphragm (subphrenic distant lymph nodes, SUB-DLN), liver, lung, and other lesions beyond bone/lung/distant lymph node above the diaphragm (supraphrenic other lesions, SUP-OL); other lesions beyond bone/liver/distant lymph node below the diaphragm (subphrenic other lesions, SUB-OL); the subtotal above the diaphragm (supraphrenic total lesions, SUP-TL); and the subtotal below the diaphragm (subphrenic total lesions, SUB-TL).

[Role of 18F-FDG PET/CT in diagnosis and staging of nasopharyngeal carcinoma].

Background & Objective: Because (18)F-FDG PET/CT can display cancer lesion morphology, size and the relatinship of the cancer lesion to adjacent tissues, it is used in the diagnosis and classification of nasopharyngeal carcinoma (NPC). This study was to explore the application value of (18)F-FDG PET/CT in TNM staging by comparing the performance of MRI and PET/CT together with pathological results for some small lymph nodes.

Methods: Sixty-eight pathologically proven NPC patients were selected from Sep.

[Primary investigation of dose-effect relationship of 153Sm-EDTMP in treating multiple bone metastases].

Background & Objective: Dose calculation of radionuclide internal irradiation is a hot topic and difficulty of nuclear medical researches. This study was to calculate the focus absorption dose of 153Sm-EDTMP with the Monte Carlo EGS4 method for treatment of bone metastases from nasopharyngeal carcinoma or breast cancer, and investigate the relationship between the focus absorption dose and painkilling effect of 153Sm-EDTMP.

Methods: Four patients with multiple bone metastases from nasopharyngeal or breast carcinoma and suffered from grade IV bone pain were treated with radionuclide internal irradiation of 153Sm-EDTMP.

[Application of molecular imaging to chemotherapy].

Molecular imaging is a new subject of exploring the biological metabolism process of the cells or organs in living organisms with some non-invasive technologies, such as PETE-CT, MR, and optical imaging instruments, using specific molecular probes to investigate the pathologic and physiologic metabolisms of the patients at molecular and gene levels. With the development of this technology, molecular imaging plays a more and more important role in guiding cancer chemotherapy, choosing sensitive medicines, planning treatment scheme, evaluating chemotherapy effect, and so on.