Publications by authors named "Sheng-Chun Hung"

Article Synopsis
  • * An auto-recruit system was implemented to remind physicians to screen for bone health, resulting in an increase in DXA screening rates from 9.5% to 33.6% within a year.
  • * Patients on ADT for longer than a year showed worse bone health, but after screenings, there was a significant rise in the use of supplements for bone health, indicating improved patient management and awareness.
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  • - This study created a temperature-resistant aptamer paired with electric double-layer Field-Effect Transistors (FETs) for detecting mercury ions effectively, leveraging the aptamer's stable hairpin structure that enhances sensitivity.
  • - Two aptamer sequences with varying melting temperatures were tested, revealing that the one with a higher melting temperature demonstrated significantly improved detection sensitivity, achieving a remarkable limit of detection of 4.68 × 10 M, much lower than previous methods.
  • - The research emphasized that both the thermal properties of aptamers and the surrounding temperature are crucial for optimizing sensor performance, particularly in differentiating between mercury and other heavy metals like arsenic and lead.
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  • The study focused on the outcomes of colon cancer patients with bladder invasion who underwent surgery at a specific hospital from 2011 to 2022.
  • Among the 41 patients, those with better surgical margins showed significantly higher overall survival rates, particularly with a median survival of 71.8 months for clean margins compared to 10.5 months for positive margins.
  • The findings suggest that complete resection can lead to better outcomes and that the choice between partial and radical cystectomy should consider both effective removal of cancer and quality of life, with factors like surgical margins and emergencies affecting survival.
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Introduction: Visceral metastasis is an important predictor for poor outcomes in prostate cancer, however, the prognostic significance surrounding the specific sites of visceral metastasis remains unclear. The aim of this study was to evaluate the impact of different visceral metastatic sites on survival in patients with prostate cancer.

Methods: We identified patients with metastatic prostate cancer between January 1, 2010 and December 31, 2023 using the TriNetX database.

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Although prostate cancer is a common occurrence among males, the relationship between existing risk prediction models remains unclear. The objective of this hospital-based retrospective study is to investigate the impact of polygenic risk scores (PRSs) on the incidence and prognosis of prostate cancer in the Han Chinese population. A total of 24,778 male participants including 903 patients with prostate cancer at Taichung Veterans General Hospital were enrolled in the study.

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Background: Given the high prevalence of BPH among elderly men, pinpointing those at elevated risk can aid in early intervention and effective management. This study aimed to explore that polygenic risk score (PRS) is effective in predicting benign prostatic hyperplasia (BPH) incidence, prognosis and risk of operation in Han Chinese.

Methods: A retrospective cohort study included 12,474 male participants (6,237 with BPH and 6,237 non-BPH controls) from the Taiwan Precision Medicine Initiative (TPMI).

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Immune checkpoint inhibitor (ICI) is an important treatment option for metastatic urothelial carcinoma (mUC) patients. A lot of clinical evidence proved the survival benefits of ICI, but cost-effectiveness of the treatment remains unclear. This study evaluates the cost-effectiveness of the ICIs treatment in different sequences among mUC patients.

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Background: The role of upfront cytoreductive nephrectomy remains debatable in the present era of tyrosine kinase inhibitors and immune checkpoint inhibitors. Here, we aimed to evaluate the outcomes of metastatic renal cell carcinoma patients treated with upfront CN and modern systemic therapies.

Methods: Using the TriNetX network database, we identified patients, in the period from 2008 to 2022, who were diagnosed with metastatic renal cell carcinoma, receiving first-line systemic therapies with tyrosine kinase inhibitors or immune checkpoint inhibitors.

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Background/aim: Prostate cancer (PCa) is lethal. Our aim in this retrospective cohort study was to use machine learning-based methodology to predict PCa risk in patients with benign prostate hyperplasia (BPH), identify potential risk factors, and optimize predictive performance.

Patients And Methods: The dataset was extracted from a clinical information database of patients at a single institute from January 2000 to December 2020.

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Background/aim: This study aimed to compare the clinical efficacy of two different Bacillus Calmette-Guérin (BCG) strains, TICE strain (OncoTICE) and Connaught strain (ImmuCyst), as a first line intravesical instillation therapy in patients with T1 high grade bladder cancer.

Patients And Methods: Patients with newly diagnosed T1 high-grade bladder cancer who underwent transurethral resection of bladder tumor (TURBT) followed by intravesical instillation therapy were enrolled. The effects of BCG strain on recurrence, progression, and side effects were analyzed using Kaplan-Meier and Cox proportional hazards models.

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Urothelial cell carcinoma (UCC) is a common malignancy of the urinary tract in Taiwan. Metastasis-Associated in Colon Cancer 1 (MACC1), a newly identified oncogene and regulator of the HGF/Met signaling pathway, has been shown to play a critical role in the development and progression of several types of cancer. Our study aims to investigate the impact of gene polymorphisms on the clinicopathological features of patients with UCC.

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Objectives: The treatment landscape for metastatic renal cell carcinoma changed a lot in the last few years. This study aimed to assess the treatment sequences and outcomes for metastatic renal cell carcinoma in a real-world setting.

Materials And Methods: We enrolled patients with metastatic renal cell carcinomawho received first-line systemic treatment with tyrosin kinase inhibitors monotherapy, ipilimumab plus nivolumab, or pembrolizumab plus axitinibbetween January2009 and May 2023 on the database of TriNetX network.

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Background/aim: With the increasing use of marginal donors, it is important to identify factors for outcomes in kidney transplantation. The aim of the present study was to evaluate the influence of surgical complications for graft survival after kidney transplantation and identify risk factors for surgical complications.

Patients And Methods: We performed a retrospective cohort study by chart review of patients who underwent kidney transplantation at the Taichung Veterans General Hospital in the period from 2007 to 2018.

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Background/aim: Extramammary Paget's disease (EMPD) is a rare, slow growing intra-epidermal malignant neoplasm that arises in areas rich in apocrine glands. Several common sites of occurrence have been reported, including the vulva, perianal region, perineum, and scrotum. Most relevant studies rely on small data bases.

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Article Synopsis
  • The study compares a nephroscope-assisted single-trocar approach to traditional laparoscopic techniques for peritoneal dialysis (PD) catheter insertion, focusing on outcomes, complications, and costs from 511 patients over 15 years.
  • Results show that the nephroscopic method has a significantly longer median catheter survival (60.5 months vs. 43.1 months) and lower rates of peritonitis and exit site infections.
  • Additionally, the nephroscopic approach is more cost-effective, saving about $16,000 annually in medical expenses, and shows no difference in complication rates between the early and later phases of the learning curve.
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Background/aim: The use of complete metastasectomy for treating metastatic renal cell carcinoma (mRCC) has been shown to improve survival outcomes in the era of tyrosine kinase inhibitors (TKIs). However, its effectiveness in combination with immune checkpoint inhibitors (ICIs) remains unclear. Therefore, the objective of the study was to elucidate the impact of metastasectomy in patients with mRCC who received both TKIs or ICIs.

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The downregulation of WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, is associated with the tumorigenesis and poor prognosis of various cancers. In this study, we investigated the associations between the polymorphisms of , clinicopathologic features of prostate cancer (PCa), and risk of postoperative biochemical recurrence (BCR). We evaluated the effects of five single-nucleotide polymorphisms (SNPs) of on the clinicopathologic features of 578 patients with PCa.

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Patients with high-risk prostate cancer after prostatectomy have a particularly high chance of being diagnosed with biochemical recurrence (BCR). Patients with BCR have a greater risk of disease progression and mortality. The present retrospective observational study aimed to clarify the risk factors for the BCR of prostate cancer after radical prostatectomy in patients with high-risk and very high-risk prostate cancer.

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Background: Testicular cancer is the most common solid cancer diagnosed among young men. Despite good response to chemotherapy and a high survival rate, subsequent salvage therapies may still be required for some patients in advanced stages. The predictive and prognostic markers are crucial unmet needs.

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  • A study was conducted to evaluate the effects of complete Radium-223 (Ra-223) treatment cycles on survival in patients with metastatic castration-resistant prostate cancer (mCRPC).
  • The analysis included 42 patients, revealing that those who completed 5-6 Ra-223 cycles experienced significantly longer median overall survival (28.5 months) compared to those with less than 4 cycles (3.93 months).
  • Factors like the number of Ra-223 cycles and pre-treatment alkaline phosphatase levels were identified as important predictors for patient survival outcomes.
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To investigate the prognostic value of the geriatric nutritional risk index (GNRI) in patients with upper tract urothelial cell carcinoma (UTUC) receiving radical nephroureterectomy (RNU). Between January 2001 and December 2015, we enrolled 488 patients with UTUC underwent RNU in Taichung Veterans General Hospital. GNRI before radical surgery was calculated based on serum albumin level and body mass index.

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Objectives: Transurethral resection of prostate (TURP) and laser prostate surgery are common surgeries for benign prostate hyperplasia (BPH). We conducted an investigation using hospital database to evaluate the clinical factors associated with post-operative usage of alpha-blockers and antispasmodics.

Methods: This study was conducted using retrospective clinical data from the hospital database, which contained newly diagnosed BPH patients between January 2007 and December 2012 who subsequently received prostate surgery.

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Article Synopsis
  • Immune checkpoint inhibitors (ICIs) like atezolizumab and pembrolizumab are increasingly used to treat advanced urothelial carcinoma (aUC), but their optimal use with chemotherapy remains debated.
  • A study analyzed 74 aUC patients treated with these ICIs to identify clinical factors affecting outcomes, finding that chemotherapy response and specific health indicators (like liver metastases) significantly influenced disease progression and survival rates.
  • Key results indicated that poor responses to chemotherapy were linked to worse outcomes with ICIs, while better ICI responses correlated with improved survival, emphasizing the importance of evaluating individual patient factors.
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Purpose: Androgen deprivation therapy (ADT) is the standard of care in advanced prostate cancer. We conducted a Taiwan National Health Insurance Research Database (NHIRD) study to evaluate the association between ADT and fracture risk in patient with prostate cancer in Taiwan.

Methods: Between 2001 and 2008, data from the Taiwan NHIRD was collected.

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