BPA exposure aggravates necroptosis of myocardial tissue in selenium deficient broilers through NO-dependent endoplasmic reticulum stress.

The environmental problem of BPA pollution has seriously endangered the health of humans and animals. As an essential trace element, the health problems caused by insufficient intake of selenium have always been widespread. Under toxic and other harmful stimuli, severe endoplasmic reticulum (ER) stress is one of multitude factors leading to death such as apoptosis and necrotic apoptosis.

Endogenous Hydrogen Sulfide Promotes Apoptosis via Mitochondrial Pathways in the Livers of Broilers with Selenium Deficiency Exudative Diathesis Disease.

Hydrogen sulfide (HS), an endogenous gasotransmitter, plays an important role in apoptosis. Exudative diathesis (ED) disease is associated with dietary selenium (Se) deficiency in broilers. The liver is one of the target organs of Se deficiency; however, little is known about the effect of HS on apoptosis via mitochondrial pathways in the livers of broilers with ED disease.