Exosomal miRNA-200b-3p regulated autogenous arteriovenous fistula thrombosis in maintenance hemodialysis patients.

Background: Autogenous arteriovenous fistula (AVF) is the best vascular hemodialysis access for terminal chronic renal failure patients but is prone to thrombosis. Pathogenic mechanisms of AVF thrombus are thus largely explored. As exosomes carry genetic content from cell of origin.

Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract.

Radix scutellariaewas used alone or in combinationwith othermedicinal herbs in the treatment oftype 2 diabetes mellitus in China. At present, the pharmacokinetics of baicalin in type 2 diabeticrats following oral administration of Radix scutellariae extract was investigated. The resultsshowed that the pharmacokinetics (especially AUC) of baicalin in type 2 diabetic rats after oraladministration of Radix scutellariae extract was remarkably different from that in normal rats.

[Isolation and identification of brine shrimp lethal activities from Derris trifoliata].

Objective: To study the brine shrimp lethal activities of the roots and stems from Derris trifoliata.

Methods: The biological activity of the athyl acetate extract was tested by the 2nd-instar of Artemia franciscana by the method of Silica gel column chromatography, Sephadex LH-20 column chromatography, Semipreparative HPLC, and their structures were elucidated by spectral analysis.

Results: Eleven compounds were isolated from the athyl acetate extract, and LD50 s of 12a-hydroxyrotenone, tephrosin, rotenone and deguelin were 0.

Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats.

Ethnopharmacological Relevance: Scutellaria-coptis herb couple (SC) is the main herb couple in many traditional Chinese compound formulas used for the treatment of diabetes mellitus, which has been used to treat diabetes mellitus for thousands of years in China. In this study we provide experimental evidence for the clinical use of SC in the treatment of diabetes mellitus.

Aim Of The Study: To confirm the anti-diabetic effect of SC extract and its main components, and to explore its mechanism from the effect on intestinal disaccharidases by in vivo and in vitro experiment.