Publications by authors named "Sheng Yu"
Objective: To explore the correlation between heart rate variability (HRV), peripheral cytokines, anxiety and pain scores in patients with breast cancer (BC).
Methods: We collected blood samples from 100 BC patients and measured the concentrations of Interleukin 6 (IL-6), Interleukin 4 (IL-4) and Interferon gamma (IFN-γ). We collected the patients' 5-minute dynamic electrocardiograms and evaluated their anxiety and pain levels through the Anxiety Self-Rating Scale and the Short-Form McGill Pain Questionnaire (SF-MPQ) Scale.
Chemodynamic therapy (CDT) utilizing Fenton or Fenton-like reactions to generate cytotoxic hydroxyl radicals by metal ions has become a compelling strategy for cancer treatment. Visualizing intratumoral Fenton or Fenton-like reactions especially at a cellular level in real-time can directly monitor the process of CDT, which is not yet feasible. Here, we present a molecule BADA chelating Cu to form Cu-BADA nanoparticles, exhibiting fluorescence quenching properties through intermolecular electron transfer.
View Article and Find Full Text PDFA photocatalytic sulfamoylation/5- cyclization of ()-'-arylidene--phenylmethacrylohydrazides with sulfamoyl chlorides was developed. The chemoselective intramolecular addition of the carbon-centered radical intermediate to the CN bond in the hydrazone motif gave the sulfamoylated pyrazolin-5-one. Besides, sulfonyl chlorides are also suitable reaction partners to access sulfonylated pyrazolin-5-ones.
View Article and Find Full Text PDFDepression decreases immunity and PD-L1 inhibitor efficacy via the hypothalamic-pituitary-adrenal (HPA) axis in triple-negative breast cancer.
Biochim Biophys Acta Mol Basis Dis
February 2025
Background: Depression weakens antitumor immunity, yet the underlying mechanisms linking depression and tumor growth remain unclear. This study examines the influence of depression on the hypothalamic-pituitary-adrenal (HPA) axis, immunological function, and effectiveness of immunotherapy in triple-negative breast cancer (TNBC) patients.
Methods: A mouse model of comorbid TNBC and depression was established via chronic restraint stress (CRS) and 4T1 tumor transplantation.
Nominal technical terms (NTTs), as crucial builders for disciplinary knowledge, can cause difficulties for students. However, previous studies have rarely associated NTTs with disciplinary knowledge construction. Apart from that, scholars of English for Specific Purposes (ESP) have mainly focused on making wordlists for one specific discipline based on corpora rather than on meanings.
View Article and Find Full Text PDFPurpose: To explore the effect of nurse-led psychological interventions on diabetes distress, depression, and glycemic control in individuals with type 2 diabetes mellitus (T2DM).
Method: Seven databases were systematically searched. Outcome measures were diabetes distress, depression, and hemoglobin A1c (HbA1c) level.
Background: Researchers gradually focus on the relationship between phage and cancer.
Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer.
Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023.
MEMS gyroscopes are well known for their outstanding advantages in Cost Size Weight and Power (CSWaP), which have inspired great research attention in recent years. A higher signal-to-noise ratio (SNR) for MEMS gyroscopes operating at larger vibrating amplitudes provides improved measuring resolution and ARW performance. However, the increment of amplitude causes strong nonlinear effects of MEMS gyroscopes due to their micron size, which has negative influences on the performance.
View Article and Find Full Text PDFArticle Synopsis
- - Endothelial cell dysfunction and vascular leakage are key issues in blood stasis syndrome (BSS), prompting research into treatments that can restore vascular integrity.
- - A novel acidic polysaccharide (TPP-4) from Typhae Pollen was isolated and characterized using advanced techniques like spectroscopy and chromatography, revealing its structure as a heteropolysaccharide.
- - TPP-4 demonstrated significant potential in improving vascular integrity in both lab (HUVECs) and live models (zebrafish), acting through the VEGFA/PI3K/mTOR signaling pathway and impacting lipid metabolism, particularly in cases of inflammation.
Psoriasis is a chronic, immune-mediated disorder characterized by immune regulation disorders and abnormal keratinocyte proliferation. Deucravacitinib (Deu), a selective oral Tyrosine Kinase 2 (TYK2) inhibitor, shows promise in treating psoriasis but may cause systemic side effects and fail to address persistent localized thickened lesions. Herein, a self-locking microneedle (MN) patch with a polyvinyl alcohol (PVA) inner ring loaded with Deu is developed, designed to penetrate the transdermal barriers and dissolve rapidly, downregulating the IL-23/IL-17 pathway and serve as the first line of defense against the spread of skin-originated inflammation.
View Article and Find Full Text PDFArticle Synopsis
- Photothermal and photodynamic therapies are promising for treating bacteria and tumors but struggle with delivering heat and reactive oxygen species (ROS) effectively to their targets.
- The researchers developed exosome-decorated bio-heterojunctions (E-bioHJ) made from MXene, liquid metal, and CT26 cell exosomes to improve therapeutic outcomes by decreasing the transfer distance of heat and ROS.
- E-bioHJ facilitates targeted delivery to tumor cells, enhancing the generation of heat and ROS under near-infrared radiation, leading to mitochondrial dysfunction and cell death, thereby presenting a new approach to improve the effectiveness of these therapies.
Heart rate variability and insomnia in depressed patients with breast cancer.
BMJ Support Palliat Care
October 2024
Article Synopsis
- The study investigates how different levels of depression affect autonomic nervous system regulation in breast cancer patients, specifically through heart rate variability (HRV) metrics.
- A total of 115 breast cancer patients were categorized based on their depression severity using the Self-Rating Depression Scale, and various HRV parameters were measured alongside sleep quality.
- Findings indicate that patients with mild to severe depression show significant differences in HRV metrics and sleep quality compared to non-depressed individuals, highlighting that higher depression correlates with issues in cardiac dynamics and sleep disturbances.
Article Synopsis
- * The article explores combining adsorption, which gathers pollutants on a solid surface, with Fenton oxidation, an advanced process using radicals to break down these contaminants, to enhance water treatment.
- * It discusses the mechanisms of both methods, various materials used in this process (like activated carbon and clays), and how this integrated approach can effectively treat different types of wastewater, including medical and industrial sources.
Article Synopsis
- KORTUC, a treatment combining hydrogen peroxide and sodium hyaluronate, shows promise in reducing hypoxic conditions in tumors after being injected directly into them, potentially improving cancer treatment outcomes.
- In tests using human tumor models, KORTUC led to a notable decrease in hypoxia markers and increased reactive oxygen species levels, indicating enhanced oxygen availability in cancerous tissues.
- If successful in ongoing clinical trials, KORTUC could transform radiation therapy for various cancers, particularly those where low oxygen levels limit treatment effectiveness.
Article Synopsis
- - Liver fibrosis happens due to an overactive healing response, primarily driven by activated hepatic stellate cells (aHSCs) that accumulate extracellular matrix (ECM) in the liver.
- - Inducing senescence (a growth halt) in aHSCs can help break down ECM and reduce fibrosis, with ATP6V1G3 being identified as a key factor in this process that needs further exploration.
- - Preliminary findings suggest that inhibiting ATP6V1G3 can trigger senescence in aHSCs, and blocking the Notch1 pathway can reverse this effect, highlighting ATP6V1G3 as a potential target for treating liver fibrosis.
Article Synopsis
- Traditional Chinese medicine has utilized seeds for centuries to treat various ailments, but the chemical profile of dispensing granules (GSDG) made from these seeds remains unclear, hindering deeper research.
- This study employed advanced analytical methods, including high performance liquid chromatography and mass spectrometry, to identify 56 components in GSDG, such as amino acids, organic acids, and flavonoids.
- The quantitative analysis highlighted -(-glucopyranosyl)-indoleacetylaspartate as the most abundant compound in GSDG, establishing a foundational understanding for its quality control and preparation technology.
Article Synopsis
- Hepatocellular carcinoma (HCC) is an aggressive liver cancer with a poor prognosis, prompting the need for ongoing research into drug therapies alongside surgical options.
- The study focuses on apolipoprotein A-I binding protein (AIBP), which is involved in cholesterol metabolism and inflammation, to understand its role in HCC cell proliferation and migration through MAPK signaling pathways.
- Results showed that AIBP expression is significantly higher in HCC tissues compared to normal tissues, correlating with a worse prognosis; manipulating AIBP levels affected cell growth and movement, linking it to the activation of specific genes in the MAPK pathway.
6-D Object Pose Estimation Based on Point Pair Matching for Robotic Grasp Detection.
IEEE Trans Neural Netw Learn Syst
September 2024
Article Synopsis
- The 6-D pose estimation is important for robotic grasping and currently relies on keypoint correspondence, which asks for accurate detection of object keypoints in real environments.* -
- Existing methods like RANSAC-based PnP struggle with differentiability in training, while direct regression approaches are fast but less accurate in pose estimation, prompting the need for improvement.* -
- The proposed PPM6D method combines RGB features with point cloud data through a cross-fusion module, utilizes an attention mechanism, and matches points effectively, leading to superior performance in pose estimation over traditional keypoint methods.*
Advances in the synthesis of functionalized tetrahydropyridazines from hydrazones.
Org Biomol Chem
October 2024
The tetrahydropyridazine motif is widely present in plenty of natural products and biologically active molecules. Easily prepared from the condensation of carbonyls with hydrazines, hydrazones are versatile synthetic building blocks that are frequently used in organic synthesis. Hydrazones are also utilized in the synthesis of nitrogen-containing molecules, especially nitrogen-containing heterocycles.
View Article and Find Full Text PDFArticle Synopsis
- * A newly designed core-shelled structure, PEG-Au@CuS NSs, improves the excretion of gold nanoparticles in mice compared to traditional PEG-AuNPs.
- * The enhanced Raman signal and photothermal conversion ability of PEG-Au-DTTC@CuS NSs allow for effective intraoperative imaging and therapy, achieving complete tumor eradication in a study with colon tumor-bearing mice.
Article Synopsis
- Raman spectroscopy with surface-enhanced Raman scattering (SERS) nanoprobes is a super-sensitive technique for in vivo imaging but faces challenges due to safety concerns with metal substrates.* -
- A new technique called stacking-induced charge transfer-enhanced Raman scattering (SICTERS) uses self-stacking small molecules to enhance Raman signals without metal substrates, achieving a Raman scattering cross-section 1350 times greater than traditional SERS gold nanoprobes.* -
- SICTERS offers better imaging sensitivity, resolution, and depth for noninvasive Raman imaging of blood and lymphatic vessels, making it a promising alternative to traditional SERS methods.*
Article Synopsis
- - The study investigates how neighborly relations affect self-neglect in elderly individuals using a self-neglect measurement scale.
- - Results show that having good relationships with neighbors significantly lowers the risk of various forms of self-neglect, with reductions ranging from 56.8% to 89.9%.
- - The conclusion emphasizes that building harmonious neighborly connections can serve as an important protective factor against self-neglect in older adults.
Article Synopsis
- - The study investigates the relationship between the substantia nigra hyperechogenicity (SN+) detected by transcranial sonography and the severity of Parkinson's disease (PD), discovering a U-shaped correlation as PD progresses through different stages.
- - A total of 612 PD patients were analyzed using the Unified Parkinson's Disease Rating Scale (UPDRS) scores, showing that in early stages (H-Y stage 1), a larger SN+ area correlated with less disease severity, while in advanced stages (H-Y stage 3 and above), a larger SN+ area correlated with greater disease severity.
- - The findings suggest that the evolution of SN+ area correlations with UPDRS scores may reflect changing pathological mechanisms related
Article Synopsis
- Alzheimer's disease (AD) is a growing concern with no effective treatments, prompting researchers to utilize knowledge graphs (KGs) for drug repurposing and biomarker discovery by examining the relationships among various biological entities related to AD.* -
- The study involved annotating 800 PubMed abstracts and employing GPT-4 for data enhancement, leading to the creation of an Alzheimer's Disease Knowledge Graph (ADKG) that identified over 3 million entity mentions and relationships among approximately 5,000 entities.* -
- The ADKG was integrated with other biomedical databases and used to train predictive models, showing superior performance in analysis compared to existing methods, highlighting its potential role in advancing Alzheimer's research and hypothesis generation.*
Indigenous microalgae-bacteria consortium (IMBC) offers significant advantages for swine wastewater (SW) treatment including enhanced adaptability and resource recovery. In this review, the approaches for enriching IMBC both in situ and ex situ were comprehensively described, followed by symbiotic mechanisms for IMBC which involve metabolic cross-feeding and signal transmission. Strategies for enhancing treatment efficiencies of SW-originated IMBC were then introduced, including improving SW quality, optimizing system operating conditions, and adjusting microbial activities.
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