Publications by authors named "Sheng Y Lee"
This study aimed to verify the effects of participation motivation in sports climbing on leisure satisfaction and physical self-efficacy. Structural equation modeling was used to analyze the causal relationships between participation motivation in sports climbing, leisure satisfaction, and physical self-efficacy, and to determine participation motivation. This study examined this causal relationship by verifying leisure satisfaction's mediating effect on the relationship between participation motivation in sports climbing and physical self-efficacy.
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- Scientists found out that a substance called adenosine helps certain pancreatic cancer cells avoid being attacked by the immune system, making it harder to treat the cancer with immunotherapy.
- They used special tests on mice with pancreatic cancer to study how this adenosine affects the environment around the tumor and how immune cells behave there.
- The researchers discovered that blocking adenosine can slow down tumor growth and make other cancer treatments work better by changing how immune cells are present in the tumor area.
Ageing is associated with increased vulnerability to environmental cold exposure. Previously, we identified the role of the cold-sensitive transient receptor potential (TRP) A1, M8 receptors as vascular cold sensors in mouse skin. We hypothesised that this dynamic cold-sensor system may become dysfunctional in ageing.
View Article and Find Full Text PDFGram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis or transport pathways causes the externalization of PLs to the outer leaflet of the OM and leads to OM permeability defects. Here, we used metabolic labeling to detect a compromised OM in intact bacteria.
View Article and Find Full Text PDFThe purpose of this study was to fine-tune the mechanical properties of high molecular-weight poly-L-lactic acid (PLLA), especially to increase its toughness without sacrificing too much of its original strength. Besides of its long degradation time, PLLA is usually hard and brittle, which hinders its usage in medical applications, i.e.
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