Publications by authors named "Sheng Wan"

Background: The occurrence of urinary tract or kidney infection is correlated with intelligence, noncognitive education and cognition, but the causal relationship between them remains uncertain, and which risk factors mediate this causal relationship remains unknown.

Methods: The intelligence (n=269,867), noncognitive education (n=510,795) and cognition data (n=257,700) were obtained from genome-wide association studies (GWAS) conducted in individuals of European ethnicities. The genetic associations between these factors and urinary tract or kidney infection (UK Biobank, n=397,867) were analyzed using linkage disequilibrium score regression.

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Optical and acoustic metagratings have addressed the challenges of low-efficiency wave manipulation and high-complexity fabrication associated with metamaterials and metasurfaces. In this research, the concept of locally resonant elastic metagrating (LREM) is both theoretically and experimentally demonstrated, which is underpinned by the unique elastic impedance modulation and the hybridization of intrinsic evanescent waves. Remarkably, the LREM overcomes the size limitations of conventional metagratings and offers a distinctive design paradigm for highly efficient, compact, and lightweight structures for wave manipulation in elastic wave systems.

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Chemotherapy-induced alopecia (CIA), commonly associated with agents such as cyclophosphamide (CYP), is a prevalent and distressing side effect of numerous chemotherapeutic treatments, significantly impacting patients' quality of life. S100A8, a calcium-binding protein involved in inflammatory responses and oxidative stress regulation, plays a pivotal role in cellular homeostasis. In this study, we investigated the involvement of S100A8 in ferroptosis within a CYP-induced CIA mouse model.

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The ongoing COVID-19 pandemic has underscored the importance of strong immune defenses against emerging SARS-CoV-2 variants. While COVID-19 vaccines containing XBB subvariants have proven effective in neutralizing new SARS-CoV-2 variants, a gap remains in knowledge regarding neutralizing antibody responses in older adults aged >65 years against these newly emerged variants. This study was therefore undertaken to investigate and compare neutralizing antibody responses to three XBB-containing protein-based vaccines (trivalent XBB.

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Background: Maintenance hemodialysis (MHD) is an effective treatment for patients with end-stage renal disease. Although MHD can prolong the survival of patients, their quality of life is lower and the fatality rate is higher. This work analyzed the factors related to the autogenous arteriovenous fistula (AVF)-like expansion of non-diabetic MHD patients by vascular ultrasound (VUS).

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Objective: To investigate the risk factors for peritonitis in peritoneal dialysis patients and to develop and validate a predictive model.

Methods: A total of 219 patients undergoing continuous ambulatory peritoneal dialysis (CAPD) who had their first peritoneal dialysis catheter placement and regular follow-up at Wuhan No. 1 Hospital between April 2020 and August 2023 were included in this study.

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Alkali stress is one of the most serious abiotic stresses limiting crop yield and it has become an increasingly serious global problem in recent years. Alkalinity tolerance (AT) at the seedling stage is one of the determinant factors for establishment of rice population under alkaline stress condition. Here, we evaluated and measured seven traits related to AT of 528 diverse rice accessions at the seedling stage.

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Introduction: Urinary incontinence (UI) significantly impairs women's quality of life. Identifying its risk factors is essential for developing effective interventions. Sarcopenia, characterized by the accelerated loss of muscle mass and function, is an emerging concern often linked to obesity and abnormal metabolic status, exacerbating various adverse health outcomes.

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Article Synopsis
  • The study analyzed 140 dust samples from various indoor settings to investigate the presence of twelve different amine-based rubber additives, revealing significant detection rates for several compounds.
  • The highest concentrations of these additives were found in parking lots, suggesting that vehicle-related sources contribute heavily to indoor pollution, although they were also present in non-vehicle environments like markets and hotels.
  • The research underscores potential health risks, especially for toddlers who have the highest estimated daily intake of these additives through dust ingestion, indicating a need for further investigation and monitoring of indoor air quality regarding these compounds.
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Objective: Our study aimed to investigate the association between maternal pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and impaired pelvic floor muscle (PFM) morphology and function during the early postpartum period.

Methods: This retrospective cohort study was conducted at Shanghai First Maternity and Infant Hospital from December 2020 to December 2022. A total of 1118 primiparous women with singleton pregnancies who underwent vaginal deliveries and participated in postpartum PFM assessments were included.

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  • The advancements in sequencing technologies have led to large datasets that enable detailed analysis of diseases, particularly helping to validate new hypotheses related to their causes and treatments.
  • Researchers are focusing on androgenetic alopecia (AGA), a common hair loss issue, revealing abnormal changes in mRNA, proteins, and metabolites which could lead to new biomarkers for the condition.
  • The review discusses the integration of various omics data (genomics, transcriptomics, proteomics, metabolomics) alongside clinical data to understand AGA better, while also addressing the challenges in combining these data types and advocating for collaborative multi-omics studies to improve insights into AGA’s mechanisms.
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The electrochemical production of hydrogen peroxide (HO) using metal-free catalysts has emerged as a viable and sustainable alternative to the conventional anthraquinone process. However, the precise architectural design of these electrocatalysts poses a significant challenge, requiring intricate structural engineering to optimize electron transfer during the oxygen reduction reaction (ORR). Herein, we introduce a novel design of covalent organic frameworks (COFs) that effectively shift the ORR from a four-electron to a more advantageous two-electron pathway.

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Exosomes derived from bone marrow-derived mesenchymal stem cells (BMSCs) can alleviate the symptoms of pelvic floor dysfunction (PFD) in rats. However, the potential therapeutical effects of exosomes derived from BMSCs treated with tumour necrosis factor (TNF)-α on the symptoms of PFD in rats are unknown. Exosomes extracted from BMSCs treated with or without TNF-α were applied to treat PFD rats.

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Background: Regulatory T cells (Tregs) play vital roles in controlling immune reactions and maintaining immune tolerance in the body. The targeted destruction of epidermal melanocytes by activated CD8T cells is a key event in the development of vitiligo. However, Tregs may exert immunosuppressive effects on CD8T cells, which could be beneficial in treating vitiligo.

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  • Alopecia areata (AA) is an autoimmune hair loss condition, with unclear links to allergic disorders like eczema, hay fever, and asthma.
  • This study investigates the genetic connections between atopic allergies and AA using data from over a million people, testing the hypothesis that these allergies may increase AA risk.
  • Results show a significant genetic link, particularly with hay fever, eczema, and asthma, suggesting that those with these conditions should be monitored for early signs of AA.
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  • Alopecia areata is a condition where the body's immune system mistakenly attacks hair follicles, causing hair loss.
  • New research shows that certain chemicals in our nerves might be making this problem worse by causing inflammation around the hair follicles.
  • Scientists are still trying to fully understand how the immune system and nervous system work together in this condition.
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  • Two-dimensional covalent organic frameworks (COFs) and their derivatives are effective electrocatalysts due to their unique structures and high surface area.
  • This study explores creating a non-stable Pt-N coordination site by electrochemically modifying platinum atoms in a 2D COF to serve as an efficient, conductive catalyst for the hydrogen evolution reaction (HER).
  • Findings demonstrate that the nitrogen-rich COF not only improves the interaction between platinum and hydrogen intermediates but also boosts electron transport and stability in acidic conditions.
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Background: We devoted ourselves to proving that the initial transthoracic echocardiography score (TTES) had predictive significance for patients with continuous ambulatory peritoneal dialysis (CAPD).

Methods: In this retrospective analysis, 274 CAPD patients who had PD therapy were recruited sequentially. TTE exams were performed three months following the start of PD therapy.

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  • * A total of 111 dust samples revealed that traditional QAC concentrations ranged from 13.8 to 150 μg/g, with emerging QACs making up 19 to 42% of the total QAC composition in various microenvironments.
  • * Notably, dust from cinemas showed higher total QAC concentrations compared to homes, and rooms with carpets had significantly greater QAC levels than those without, highlighting the prevalence of these compounds in indoor environments.
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Single-cell technologies offer unprecedented opportunities to dissect gene regulatory mechanisms in context-specific ways. Although there are computational methods for extracting gene regulatory relationships from scRNA-seq and scATAC-seq data, the data integration problem, essential for accurate cell type identification, has been mostly treated as a standalone challenge. Here we present scTIE, a unified method that integrates temporal multimodal data and infers regulatory relationships predictive of cellular state changes.

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Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors, as a new type of hypoglycemic drug, can prevent proximal renal tubule injury related to glucose toxicity and play a renoprotective role. Canagliflozin, a recognized SGLT-2 inhibitor, has been proved to have potential protection in diabetic nephropathy (DN), but its mechanism has not been fully elucidated. In this study, the protective effect of canagliflozin against high glucose (HG)-induced renal tubular epithelial cell (NRK-52E) injury in vitro was assessed.

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Preeclampsia is a pregnancy disorder characterized by systemic organ damage and high blood pressure. It has been reported that microRNA-195 (miR-195) is associated with preeclampsia. In this study, we discovered the target of miR-195 in regulating human extravillous cytotrophoblast-derived transformed cell proliferation and migration.

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Contrastive learning (CL) is a prominent technique for self-supervised representation learning, which aims to contrast semantically similar (i.e., positive) and dissimilar (i.

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