Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties.

Catalytic conversion of hydrogen peroxide (HO) to more toxic hydroxyl radicals (OH) is a good choice for sterilization and anti-infection, but endogenous HO is insufficient to achieve satisfactory sterilization efficacy. Despite great efforts, designing and developing antimicrobial materials that specifically and effectively self-supply HO at the wound site remain as tremendous challenges. Here, we report a pH-responsive copper peroxide-loaded wound dressing made from copper hydroxide and gelatin sponge and then reacted with HO.

Hydrogel sunscreen based on yeast /gelatin demonstrates excellent UV-shielding and skin protection performance.

Traditional organic and inorganic sunscreens suffer from the disadvantages of low stability and poor biocompatibility. In the study, we developed a novel hydrogel sunscreen based on the yeast and gelatin, which demonstrated excellent UV protection property and broad absorption of UV across UVA and UVB region. Yeast was used as effective component and gelatin as matrix to fabricate the hydrogel, which is high hydrated and reasonable to simulate natural living tissue.

[Subacute toxicity and chemical analysis of Tibetan medicine Oxytropis falcata].

Four different extracts of Oxytropis falcata, including the aerial aqueous extract, and the underground aqueous extract, the aerial lipophilic extract, and the underground lipophilic extract were prepared and then administrated orally to mice at the maximum dose (50 g x kg(-1) x d(-1) calculated by raw material) for fifteen days respectively. Compared with the control group, which was administrated of 1.0% tween-80, the treatment groups did not show significant differences in appearance and behavior.

[Chemical constituents from whole plants of Carduus acanthoides].

Fourteen compounds were isolated from wholeplants of Carduus acanthoides by various chromatographic techniques including column chromatography over HP-20 macroporous resin, MCI gel, silica gel, Sephadex LH-20 and ODS and reversed-phase HPLC. Their structures were identified as salidroside (1), 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (2), 3,5-di-hydroxyphenethyl alcohol-3-O-beta-D-glucopyranoside (3), p-coumaric acid (4), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl) propan-1-one (5), 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl) propan-1-one (6), syringin (7), p-hydroxybenzaldehyde (8), salicylic acid (9), tachioside (10), vanillic acid-4-O-beta-D-glucopyranoside (11), syringic aldehyde (12), 2,6-dimethoxy-4-hydroxyphenol-1-O-beta-D-glucopyranoside (13), and 2, 6-dimethoxy-p-hydroquinone-4-0-P-D-glucopyranoside (14) on the basis of spectroscopic data analysiS. All compounds were isolated from the genus Carduus for the first time except for compounds 4 and 7.

Two new glycosides from Carduus acanthoides.

Two new glycosides, syringic acid-4-O-β-L-arabinopyranoside and kaempferol-3-O-α-L-rhamnopyranosyl-7-O-β-D-glucuronopyranoside, were isolated from whole plants of Carduus acanthoides (Asteraceae), and their structures were elucidated on the basis of spectroscopic analysis.

3-Hydroxy-3-methylglutaryl flavonol glycosides from Oxytropis falcata.

Five new 3-hydroxy-3-methylglutaryl (HMG) flavonol 3-O-glycosides, named oxytroflavosides A-E (1-5), and two new rhamnocitrin 3-O-glycosides, oxytroflavosides F and G (6 and 7) were isolated from the n-BuOH-soluble fraction of an EtOH extract of Oxytropis falcata together with seven known kaempferol glycosides (8-14), of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by spectroscopic techniques and chemical methods. The absolute configuration of HMG in compounds 1-5 was determined to be S through spectroscopic analysis of the mevalonamide obtained by amidation and reduction of the HMG moiety.

[Two en-kaurene diterpenoids from Tibetan medicine Caryopteris toroetii].

Objective: To study the chemical constituents of Tibetan medicine Caryopteris toroetii.

Method: The crude drug was extracted with 95% EtOH and isolated by repeated chromatographic methods. The structures of the isolated compounds were elucidated on the basis of spectral analysis.

[Studies on chemical constituents of Tibetan medicine Caryopteris toroetii].

Objective: To study the chemical constituents of the Tibetan medicine Caryopteris toroetii.

Method: The crude drug was extracted with 95% EtOH and isolated by repeatedly chromatographic methods. The structures of the isolated compounds were elucidated by spectral analysis.

[Studies on glycosides from Gentiana veitchiorum].

Objective: To study the chemical constituents of Gentiana veitchiorum.

Method: The chemical constituents were isolated by chromatography and identified by spectral data.

Result: Five glycosides, loganic acid (1), gentiopicroside (2), isoorientin 3'-methyl ether (3), isovitexin (4), isoorientin (5) were isolated and identified.

Isolation and identification of metabolites from dihydromyricetin.

Dihydromyricetin (DHM) is the major bioactive constituent of Rattan Tea, which is the tender stems and leaves of Ampelopsis grossendentata. Seven metabolites (2-8) of DHM (1) were obtained by the chromatographic method. The metabolites 2-5 were obtained from the urine of rats administered orally with DHM; and metabolites 6-8 were detected in the fecal specimens of rats, which were also produced by human intestinal bacteria (HIB) in vitro, and were separated from the cultured media of HIB containing DHM.